Anti-SCG2 Antibody (CAB6425)
- SKU:
- CAB6425
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SCG2 Antibody |
| Antibody SKU: | CAB6425 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-320 of human SCG2 (NP_003460.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | SW620, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-320 of human SCG2 (NP_003460.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FQRN QLLQ KEPD LRLE NVQK FPSP EMIR ALEY IENL RQQA HKEE SSPD YNPY QGVS VPLQ QKEN GDES HLPE RDSL SEED WMRI ILEA LRQA ENEP QSAP KENK PYAL NSEK NFPM DMSD DYET QQWP ERKL KHMQ FPPM YEEN SRDN PFKR TNEI VEEQ YTPQ SLAT LESV FQEL GKLT GPNN QKRE RMDE EQKL YTDD EDDI YKAN NIAY EDVV GGED WNPV EEKI ESQT QEEV RDSK ENIE KNEQ INDE MKRS GQLG IQEE DLRK ESKD QLSD DVSK VIAY LKRL VNA |
| Gene ID: | 7857 |
| Uniprot: | P13521 |
| Cellular Location: | Secreted |
| Calculated MW: | 70kDa |
| Observed MW: | 65kDa |
| Synonyms: | SCG2, CHGC, EM66, SN, SgII |
| Background: | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. |
| UniProt Protein Function: | SCG2: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. Belongs to the chromogranin/secretogranin protein family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Motility/polarity/chemotaxis; Secreted; Cytokine; Secreted, signal peptide; Apoptosis Chromosomal Location of Human Ortholog: 2q35-q36 Cellular Component: extracellular space Molecular Function:chemoattractant activity; cytokine activity; protein binding Biological Process: angiogenesis; endothelial cell migration; eosinophil chemotaxis; induction of positive chemotaxis; inflammatory response; MAPKKK cascade; negative regulation of endothelial cell proliferation; positive chemotaxis; positive regulation of endothelial cell proliferation; protein secretion |
| NCBI Summary: | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13521 |
| NCBI GenInfo Identifier: | 143811457 |
| NCBI Gene ID: | 7857 |
| NCBI Accession: | P13521.2 |
| UniProt Secondary Accession: | P13521,Q53T11, Q8TBH3, B2R662, |
| UniProt Related Accession: | P13521 |
| Molecular Weight: | 70,941 Da |
| NCBI Full Name: | Secretogranin-2 |
| NCBI Synonym Full Names: | secretogranin II |
| NCBI Official Symbol: | SCG2 |
| NCBI Official Synonym Symbols: | SN; CHGC; EM66; SgII |
| NCBI Protein Information: | secretogranin-2 |
| UniProt Protein Name: | Secretogranin-2 |
| UniProt Synonym Protein Names: | Chromogranin-C; Secretogranin II; SgII |
| Protein Family: | Secretogranin |
| UniProt Gene Name: | SCG2 |
| UniProt Entry Name: | SCG2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SCG2 antibody (CAB6425) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using SCG2 antibody (CAB6425). Blue: DAPI for nuclear staining. |
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