Anti-SBDS Antibody (CAB5876)
- SKU:
- CAB5876
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SBDS Antibody |
| Antibody SKU: | CAB5876 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human SBDS (NP_057122.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, SKOV3, HepG2, HL-60, Mouse brain, Mouse lung, Rat lung, Rat ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human SBDS (NP_057122.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSIF TPTN QIRL TNVA VVRM KRAG KRFE IACY KNKV VGWR SGVE KDLD EVLQ THSV FVNV SKGQ VAKK EDLI SAFG TDDQ TEIC KQIL TKGE VQVS DKER HTQL EQMF RDIA TIVA DKCV NPET KRPY TVIL IERA MKDI HYSV KTNK STKQ QALE VIKQ LKEK MKIE RAHM RLRF ILPV NEGK KLKE KLKP LIKV IESE DYGQ QLEI VCLI DPGC FREI DELI KKET KGKG SLEV LNLK DVEE GDEK FE |
| Gene ID: | 51119 |
| Uniprot: | Q9Y3A5 |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton, nucleolus, nucleoplasm, spindle |
| Calculated MW: | 28kDa |
| Observed MW: | 34kDa |
| Synonyms: | SBDS, CGI-97, SDS, SWDS |
| Background: | This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located. |
| UniProt Protein Function: | SBDS: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS). SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities. Belongs to the SDO1/SBDS family. |
| UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 7q11.21 Cellular Component: nucleoplasm; spindle pole; cytoplasm; nucleolus; nucleus Molecular Function:rRNA binding; protein binding; microtubule binding; ribosome binding Biological Process: bone marrow development; cell proliferation; leukocyte chemotaxis; ribosomal large subunit biogenesis and assembly; inner cell mass cell proliferation; mitotic spindle stabilization; bone mineralization; rRNA processing; mature ribosome assembly Disease: Shwachman-diamond Syndrome; Aplastic Anemia |
| NCBI Summary: | This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3A5 |
| NCBI GenInfo Identifier: | 28380824 |
| NCBI Gene ID: | 51119 |
| NCBI Accession: | Q9Y3A5.4 |
| UniProt Secondary Accession: | Q9Y3A5,Q96FX0, Q9NV53, A8K0P4, |
| UniProt Related Accession: | Q9Y3A5 |
| Molecular Weight: | 250 |
| NCBI Full Name: | Ribosome maturation protein SBDS |
| NCBI Synonym Full Names: | Shwachman-Bodian-Diamond syndrome |
| NCBI Official Symbol: | SBDS |
| NCBI Official Synonym Symbols: | SDS; SWDS; CGI-97 |
| NCBI Protein Information: | ribosome maturation protein SBDS |
| UniProt Protein Name: | Ribosome maturation protein SBDS |
| UniProt Synonym Protein Names: | Shwachman-Bodian-Diamond syndrome protein |
| Protein Family: | Ribosome maturation protein |
| UniProt Gene Name: | SBDS |
| UniProt Entry Name: | SBDS_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SBDS antibody (CAB5876) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using SBDS antibody (CAB5876) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of MCF-7 cells using SBDS antibody (CAB5876). Blue: DAPI for nuclear staining. |
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