Anti-SAA1 항체 (CAB1655)

Antibody Name:	Anti-SAA1 Antibody
Antibody SKU:	CAB1655
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 19-122 of human SAA1 (NP_000322.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	SW480

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 19-122 of human SAA1 (NP_000322.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	RSFF SFLG EAFD GARD MWRA YSDM REAN YIGS DKYF HARG NYDA AKRG PGGA WAAE VISD AREN IQRF FGHG AEDS LADQ AANE WGRS GKDP NHFR PAGL PEKY
Gene ID:	6288
Uniprot:	P0DJI8
Cellular Location:	Secreted
Calculated MW:	13kDa
Observed MW:	14kDa

Synonyms:

SAA1, PIG4, SAA, SAA2, TP53I4

Background:

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.

UniProt Protein Function:	SAA1: Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: extracellular region Molecular Function:heparin binding; G-protein-coupled receptor binding Biological Process: positive regulation of interleukin-1 secretion; receptor-mediated endocytosis; platelet activation; neutrophil chemotaxis; elevation of cytosolic calcium ion concentration; positive regulation of cell adhesion; regulation of protein secretion; negative regulation of inflammatory response; acute-phase response; innate immune response; lymphocyte chemotaxis; macrophage chemotaxis; positive regulation of cytokine secretion
NCBI Summary:	This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
UniProt Code:	P0DJI8
NCBI GenInfo Identifier:	395406826
NCBI Gene ID:	6288
NCBI Accession:	P0DJI8.1
UniProt Secondary Accession:	P0DJI8,P02735, P02736, P02737, Q16730, Q16834, Q16835 Q16879, Q3KRB3, Q6FG67, Q96QN0, Q9UCK9,
UniProt Related Accession:	P0DJI8
Molecular Weight:	122
NCBI Full Name:	Serum amyloid A-1 protein
NCBI Synonym Full Names:	serum amyloid A1
NCBI Official Symbol:	SAA1
NCBI Official Synonym Symbols:	SAA; PIG4; SAA2; TP53I4
NCBI Protein Information:	serum amyloid A-1 protein; serum amyloid A protein; tumor protein p53 inducible protein 4
UniProt Protein Name:	Serum amyloid A-1 protein
UniProt Synonym Protein Names:	Amyloid fibril protein AA
UniProt Gene Name:	SAA1
UniProt Entry Name:	SAA1_HUMAN

Western blot analysis of extracts of SW480 cells, using SAA1 antibody (CAB1655) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Antibodies	ELISA Kits
Anti-SAA1 Antibody (CAB14553)	Human SAA (Serum Amyloid A) CLIA Kit (HUES01152)
	Human Serum amyloid A-1 protein (SAA1) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)