Anti-SAA1 Antibody (CAB14553)
- SKU:
- CAB14553
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-SAA1 Antibody |
| Antibody SKU: | CAB14553 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SAA1 (NP_000322.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SAA1 (NP_000322.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKLL TGLV FCSL VLGV SSRS FFSF LGEA FDGA RDMW RAYS DMRE ANYI GSDK YFHA RGNY DAAK RGPG GAWA AEVI SDAR ENIQ RFFG HGAE DSLA DQAA |
| Gene ID: | 6288 |
| Uniprot: | P0DJI8 |
| Cellular Location: | Secreted |
| Calculated MW: | 13kDa |
| Observed MW: | 16kDa |
| Synonyms: | SAA1, PIG4, SAA, SAA2, TP53I4 |
| Background: | This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. |
| UniProt Protein Function: | SAA1: Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: extracellular region Molecular Function:heparin binding; G-protein-coupled receptor binding Biological Process: positive regulation of interleukin-1 secretion; receptor-mediated endocytosis; platelet activation; neutrophil chemotaxis; elevation of cytosolic calcium ion concentration; positive regulation of cell adhesion; regulation of protein secretion; negative regulation of inflammatory response; acute-phase response; innate immune response; lymphocyte chemotaxis; macrophage chemotaxis; positive regulation of cytokine secretion |
| NCBI Summary: | This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012] |
| UniProt Code: | P0DJI8 |
| NCBI GenInfo Identifier: | 395406826 |
| NCBI Gene ID: | 6288 |
| NCBI Accession: | P0DJI8.1 |
| UniProt Secondary Accession: | P0DJI8,P02735, P02736, P02737, Q16730, Q16834, Q16835 Q16879, Q3KRB3, Q6FG67, Q96QN0, Q9UCK9, |
| UniProt Related Accession: | P0DJI8 |
| Molecular Weight: | 122 |
| NCBI Full Name: | Serum amyloid A-1 protein |
| NCBI Synonym Full Names: | serum amyloid A1 |
| NCBI Official Symbol: | SAA1 |
| NCBI Official Synonym Symbols: | SAA; PIG4; SAA2; TP53I4 |
| NCBI Protein Information: | serum amyloid A-1 protein; serum amyloid A protein; tumor protein p53 inducible protein 4 |
| UniProt Protein Name: | Serum amyloid A-1 protein |
| UniProt Synonym Protein Names: | Amyloid fibril protein AA |
| UniProt Gene Name: | SAA1 |
| UniProt Entry Name: | SAA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SAA1 antibody (CAB14553) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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