Anti-RTN3 Antibody (CAB15129)
- SKU:
- CAB15129
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-RTN3 Antibody |
| Antibody SKU: | CAB15129 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RTN3 (NP_006045.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RTN3 (NP_006045.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YKSV IQAV QKSE EGHP FKAY LDVD ITLS SEAF HNYM NAAM VHIN RALK LIIR LFLV EDLV DSLK LAVF MWLM TYVG AVFN GITL LILA ELLI FSVP IVYE KYKT QIDH YVGI ARDQ TKSI VEKI QAKL PGIA KKKA E |
| Gene ID: | 10313 |
| Uniprot: | O95197 |
| Cellular Location: | Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein |
| Calculated MW: | 23kDa/25kDa/26kDa/27kDa/100kDa/110kDa/112kDa |
| Observed MW: | 26kDa |
| Synonyms: | RTN3, ASYIP, HAP, NSPL2, NSPLII, RTN3-A1 |
| Background: | This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. |
| UniProt Protein Function: | RTN3: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q13 Cellular Component: Golgi membrane; extracellular space; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane Biological Process: vesicle-mediated transport; viral reproduction; apoptosis |
| NCBI Summary: | This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012] |
| UniProt Code: | O95197 |
| NCBI GenInfo Identifier: | 134047900 |
| NCBI Gene ID: | 10313 |
| NCBI Accession: | O95197.2 |
| UniProt Secondary Accession: | O95197,Q147U9, Q496K2, Q53GN3, Q59EP0, Q5UEP2, Q6T930 Q7RTM7, B3KQS2, B7Z308, B7Z4M0, F5H774, |
| UniProt Related Accession: | O95197 |
| Molecular Weight: | 1032 |
| NCBI Full Name: | Reticulon-3 |
| NCBI Synonym Full Names: | reticulon 3 |
| NCBI Official Symbol: | RTN3 |
| NCBI Official Synonym Symbols: | HAP; ASYIP; NSPL2; NSPLII; RTN3-A1 |
| NCBI Protein Information: | reticulon-3; NSP-like protein 2; NSP-like protein II; homolog of ASY protein; ASY interacting protein; neuroendocrine-specific protein-like 2; neuroendocrine-specific protein-like II |
| UniProt Protein Name: | Reticulon-3 |
| UniProt Synonym Protein Names: | Homolog of ASY protein; HAP; Neuroendocrine-specific protein-like 2; NSP-like protein 2; Neuroendocrine-specific protein-like II; NSP-like protein II; NSPLII |
| Protein Family: | Reticulon |
| UniProt Gene Name: | RTN3 |
| UniProt Entry Name: | RTN3_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using RTN3 antibody (CAB15129) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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