| Synonyms: | RPS6KA2, HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, p90RSK2, pp90RSK3 |
| UniProt Protein Function: | RSK3: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Tumor suppressor; Protein kinase, AGC; Translation; EC 2.7.11.1; AGC group; RSK family; RSK subfamily Chromosomal Location of Human Ortholog: 6q27 Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; spindle; cytosol; nucleus Molecular Function:protein serine/threonine kinase activity; protein binding; magnesium ion binding; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; ATP binding Biological Process: axon guidance; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; heart development; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; oocyte maturation; brain renin-angiotensin system; toll-like receptor 2 signaling pathway; negative regulation of cell cycle; toll-like receptor 10 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; negative regulation of cell proliferation; synaptic transmission; peptidyl-serine phosphorylation; heart contraction; negative regulation of meiosis; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway |
| NCBI Summary: | This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15349 |
| NCBI GenInfo Identifier: | 90110031 |
| NCBI Gene ID: | 6196 |
| NCBI Accession: | Q15349.2 |
| UniProt Secondary Accession: | Q15349,Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5, B3KTK9 |
| UniProt Related Accession: | Q15349 |
| Molecular Weight: | 84,014 Da |
| NCBI Full Name: | Ribosomal protein S6 kinase alpha-2 |
| NCBI Synonym Full Names: | ribosomal protein S6 kinase, 90kDa, polypeptide 2 |
| NCBI Official Symbol: | RPS6KA2 |
| NCBI Official Synonym Symbols: | RSK; HU-2; RSK3; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2 |
| NCBI Protein Information: | ribosomal protein S6 kinase alpha-2; 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; RSK-3; S6K-alpha-2; p90-RSK 2; p90RSK2; ribosomal S6 kinase 3; ribosomal protein S6 kinase 90kDa polypeptide 2; ribosomal protein S6 kinase alpha 2 |
| UniProt Protein Name: | Ribosomal protein S6 kinase alpha-2 |
| UniProt Synonym Protein Names: | 90 kDa ribosomal protein S6 kinase 2; p90-RSK 2; p90RSK2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Ribosomal S6 kinase 3; RSK-3; pp90RSK3 |
| Protein Family: | Ribosomal protein S6 kinase |
| UniProt Gene Name: | RPS6KA2 |
| UniProt Entry Name: | KS6A2_HUMAN |
