Anti-RPS26 Antibody (CAB15096)
- SKU:
- CAB15096
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-RPS26 Antibody |
| Antibody SKU: | CAB15096 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RPS26 (NP_001020.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, LO2, Raji, DU145, mouse brain, mouse heart, mouse kidney, mouse liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RPS26 (NP_001020.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTKK RRNN GRAK KGRG HVQP IRCT NCAR CVPK DKAI KKFV IRNI VEAA AVRD ISEA SVFD AYVL PKLY VKLH YCVS CAIH SKVV RNRS REAR KDRT PPPR |
| Gene ID: | 6231 |
| Uniprot: | P62854 |
| Cellular Location: | |
| Calculated MW: | 13kDa |
| Observed MW: | 15kDa |
| Synonyms: | RPS26, DBA10, S26 |
| Background: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. |
| UniProt Protein Function: | RPS26: Defects in RPS26 are the cause of Diamond-Blackfan anemia type 10 (DBA10). It is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S26e family. |
| UniProt Protein Details: | Protein type:RNA-binding; Translation; Ribosomal Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytoplasm; cytosol; membrane; nucleolus; nucleoplasm; small ribosomal subunit Molecular Function:mRNA binding; protein binding; structural constituent of ribosome Biological Process: mRNA catabolic process, nonsense-mediated decay; negative regulation of RNA splicing; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription Disease: Diamond-blackfan Anemia 10 |
| NCBI Summary: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62854 |
| NCBI GenInfo Identifier: | 51338650 |
| NCBI Gene ID: | 6231 |
| NCBI Accession: | P62854.3 |
| UniProt Secondary Accession: | P62854,P02383, P70394, Q06722, Q3MHD8, Q6IRY4, |
| UniProt Related Accession: | P62854 |
| Molecular Weight: | 13,015 Da |
| NCBI Full Name: | 40S ribosomal protein S26 |
| NCBI Synonym Full Names: | ribosomal protein S26 |
| NCBI Official Symbol: | RPS26 |
| NCBI Official Synonym Symbols: | S26; DBA10 |
| NCBI Protein Information: | 40S ribosomal protein S26 |
| UniProt Protein Name: | 40S ribosomal protein S26 |
| Protein Family: | 40S ribosomal protein |
| UniProt Gene Name: | RPS26 |
| UniProt Entry Name: | RS26_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RPS26 antibody (CAB15096) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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