Anti-RPH3AL Antibody (CAB4311)
- SKU:
- CAB4311
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-RPH3AL Antibody |
| Antibody SKU: | CAB4311 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 161-315 of human RPH3AL (NP_008918.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | BT-474, 22Rv1, SW620, NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 161-315 of human RPH3AL (NP_008918.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KYIL PLKT PGRA DDPH FRPL PTEP AERE PRSS ETSR IYTW ARGR VVSS DSDS DSDL SSSS LEDR LPST GVRD RKGD KPWK ESGG SVEA PRMG FTHP PGHL SGCQ SSLA SGET GTGS ADPP GGPR PGLT RRAP VKDT PGRA PAAD AAPA GPSS CLG |
| Gene ID: | 9501 |
| Uniprot: | Q9UNE2 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, secretory vesicle membrane |
| Calculated MW: | 31kDa/34kDa |
| Observed MW: | 45kDa |
| Synonyms: | RPH3AL, NOC2 |
| Background: | The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | RPH3AL: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Acts as a potential RAB3B effector protein in epithelial cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: cytoplasm; plasma membrane Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; cytoskeletal protein binding; protein binding; syntaxin binding Biological Process: calcium ion-dependent exocytosis of neurotransmitter; exocytosis; regulation of calcium ion-dependent exocytosis; vesicle fusion |
| NCBI Summary: | The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010] |
| UniProt Code: | Q9UNE2 |
| NCBI GenInfo Identifier: | 74735140 |
| NCBI Gene ID: | 9501 |
| NCBI Accession: | Q9UNE2.1 |
| UniProt Secondary Accession: | Q9UNE2,Q9BSB3, D3DTG7, |
| UniProt Related Accession: | Q9UNE2 |
| Molecular Weight: | 31,190 Da |
| NCBI Full Name: | Rab effector Noc2 |
| NCBI Synonym Full Names: | rabphilin 3A-like (without C2 domains) |
| NCBI Official Symbol: | RPH3AL |
| NCBI Official Synonym Symbols: | NOC2 |
| NCBI Protein Information: | rab effector Noc2 |
| UniProt Protein Name: | Rab effector Noc2 |
| UniProt Synonym Protein Names: | No C2 domains protein; Rabphilin-3A-like protein |
| Protein Family: | Rab effector |
| UniProt Gene Name: | RPH3AL |
| UniProt Entry Name: | RPH3L_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RPH3AL antibody (CAB4311) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver using RPH3AL antibody (CAB4311) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using RPH3AL antibody (CAB4311) at dilution of 1:100 (40x lens). |
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