Anti-RMDN3 Antibody (CAB5820)
- SKU:
- CAB5820
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-RMDN3 Antibody |
| Antibody SKU: | CAB5820 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 171-470 of human RMDN3 (NP_060615.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HepG2, HeLa, MCF7, Mouse liver, Mouse brain, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 171-470 of human RMDN3 (NP_060615.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ESEG GYTT ANAE SDNE RDSD KESE DGED EVSC ETVK MGRK DSLD LEEE AASG ASSA LEAG GSSG LEDV LPLL QQAD ELHR GDEQ GKRE GFQL LLNN KLVY GSRQ DFLW RLAR AYSD MCEL TEEV SEKK SYAL DGKE EAEA ALEK GDES ADCH LWYA VLCG QLAE HESI QRRI QSGF SFKE HVDK AIAL QPEN PMAH FLLG RWCY QVSH LSWL EKKT ATAL LESP LSAT VEDA LQSF LKAE ELQP GFSK AGRV YISK CYRE LGKN SEAR WWMK LALE LPDV TKED LAIQ KDLE ELEV ILRD |
| Gene ID: | 55177 |
| Uniprot: | Q96TC7 |
| Cellular Location: | Cytoplasm, Mitochondrion membrane, Mitochondrion outer membrane, Nucleus, Single-pass membrane protein, cytoskeleton, spindle, spindle pole |
| Calculated MW: | 38kDa/52kDa |
| Observed MW: | 60kDa |
| Synonyms: | RMDN3, FAM82A2, FAM82C, RMD-3, RMD3, ptpip51 |
| Background: |
| UniProt Protein Function: | FAM82A2: a single-pass membrane protein in the mitochondrial membrane. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system. Induced by EGF, TGF-beta, retinoic acid-and 1,25-Dihydroxyvitamin D(3). Two alternatively spliced human isoforms may be produced. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Apoptosis; Mitochondrial Chromosomal Location of Human Ortholog: 15q15.1 Cellular Component: spindle pole; microtubule; mitochondrial outer membrane; mitochondrion; integral to membrane; nucleus Molecular Function:protein binding Biological Process: cellular calcium ion homeostasis; apoptosis; cell differentiation |
| UniProt Code: | Q96TC7 |
| NCBI GenInfo Identifier: | 147643203 |
| NCBI Gene ID: | 55177 |
| NCBI Accession: | Q96TC7.2 |
| UniProt Secondary Accession: | Q96TC7,Q6ZWE9, Q96H23, Q96SD6, Q9H6G1, Q9NVQ6, A9UMZ9 B3KRR3, |
| UniProt Related Accession: | Q96TC7 |
| Molecular Weight: | 470 |
| NCBI Full Name: | Regulator of microtubule dynamics protein 3 |
| NCBI Synonym Full Names: | regulator of microtubule dynamics 3 |
| NCBI Official Symbol: | RMDN3 |
| NCBI Official Synonym Symbols: | RMD3; RMD-3; FAM82C; FAM82A2; ptpip51 |
| NCBI Protein Information: | regulator of microtubule dynamics protein 3; cerebral protein 10; TCPTP-interacting protein 51; microtubule-associated protein; family with sequence similarity 82, member C; family with sequence similarity 82, member A2; protein tyrosine phosphatase-interacting protein 51 |
| UniProt Protein Name: | Regulator of microtubule dynamics protein 3 |
| UniProt Synonym Protein Names: | Cerebral protein 10; Protein FAM82A2; Protein FAM82C; Protein tyrosine phosphatase-interacting protein 51; TCPTP-interacting protein 51 |
| Protein Family: | Regulator of microtubule dynamics protein |
| UniProt Gene Name: | RMDN3 |
| UniProt Entry Name: | RMD3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RMDN3 antibody (CAB5820) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded Human liver using RMDN3 Rabbit pAb (CAB5820) at dilution of 1:100 (40x lens). |
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