Anti-RGS17 항체 (CAB15815)

Antibody Name:	Anti-RGS17 Antibody
Antibody SKU:	CAB15815
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 45-130 of human RGS17 (NP_036551.3).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:	Mouse brain, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 45-130 of human RGS17 (NP_036551.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NEER GENA GRPT HTTK MESI QVLE ECQN PTAE EVLS WSQN FDKM MKAP AGRN LFRE FLRT EYSE ENLL FWLA CEDL KKEQ NKKV IE
Gene ID:	26575
Uniprot:	Q9UGC6
Cellular Location:	Cytoplasm, Lipid-anchor, Membrane, Nucleus
Calculated MW:	24kDa
Observed MW:	24kDa

Synonyms:

RGS17, RGS-17, RGSZ2, hRGS17

Background:

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.

UniProt Protein Function:	RGS17: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
UniProt Protein Details:	Protein type:GAPs; GAPs, RGS Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function:GTPase activator activity Biological Process: positive regulation of GTPase activity
NCBI Summary:	This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UGC6
NCBI GenInfo Identifier:	21361405
NCBI Gene ID:	26575
NCBI Accession:	NP_036551
UniProt Secondary Accession:	Q9UGC6,Q5TF49, Q8TD61, Q9UJS8,
UniProt Related Accession:	Q9UGC6
Molecular Weight:	24,359 Da
NCBI Full Name:	regulator of G-protein signaling 17
NCBI Synonym Full Names:	regulator of G-protein signaling 17
NCBI Official Symbol:	RGS17
NCBI Official Synonym Symbols:	RGSZ2; RGS-17; hRGS17
NCBI Protein Information:	regulator of G-protein signaling 17
UniProt Protein Name:	Regulator of G-protein signaling 17
Protein Family:	Regulator of G-protein signaling
UniProt Gene Name:	RGS17
UniProt Entry Name:	RGS17_HUMAN

Western blot analysis of extracts of various cell lines, using RGS17 antibody (CAB15815) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)