Anti-RGS13 Antibody (CAB10035)
- SKU:
- CAB10035
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-RGS13 Antibody |
| Antibody SKU: | CAB10035 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-159 of human RGS13 (NP_002918.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-159 of human RGS13 (NP_002918.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSRR NCWI CKMC RDES KRPP SNLT LEEV LQWA QSFE NLMA TKYG PVVY AAYL KMEH SDEN IQFW MACE TYKK IASR WSRI SRAK KLYK IYIQ PQSP REIN IDSS TRET IIRN IQEP TETC FEEA QKIV YMHM ERDS YPRF LKSE MYQK LLKT MQSN NSF |
| Gene ID: | 6003 |
| Uniprot: | O14921 |
| Cellular Location: | |
| Calculated MW: | 19kDa |
| Observed MW: | 30kDa |
| Synonyms: | RGS13 |
| Background: | The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. |
| UniProt Protein Function: | RGS13: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)- alpha. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, RGS Chromosomal Location of Human Ortholog: 1q31.2 Cellular Component: cytoplasm; plasma membrane Molecular Function:GTPase activator activity |
| NCBI Summary: | The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14921 |
| NCBI GenInfo Identifier: | 3914622 |
| NCBI Gene ID: | 6003 |
| NCBI Accession: | O14921.1 |
| UniProt Secondary Accession: | O14921,Q6PGR2, Q8TD63, Q9BX45, |
| UniProt Related Accession: | O14921 |
| Molecular Weight: | 19,135 Da |
| NCBI Full Name: | Regulator of G-protein signaling 13 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 13 |
| NCBI Official Symbol: | RGS13 |
| NCBI Protein Information: | regulator of G-protein signaling 13 |
| UniProt Protein Name: | Regulator of G-protein signaling 13 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS13 |
| UniProt Entry Name: | RGS13_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RGS13 antibody (CAB10035) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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