Anti-RERE Antibody (CAB15255)
- SKU:
- CAB15255
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-RERE Antibody |
| Antibody SKU: | CAB15255 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human RERE (NP_036234.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HeLa, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human RERE (NP_036234.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTAD KDKD KDKE KDRD RDRD RERE KRDK ARES ENSR PRRS CTLE GGAK NYAE SDHS EDED NDNN SATA EEST KKNK KKPP KKKS RYER TDTG EITS YITE DDVV YRPG DCVY IESR RPNT PYFI CSIQ DFKL VHNS QACC RSPT PALC DPPA CSLP VASQ PPQH LSEA GRGP VGSK RDHL LMNV KWYY RQSE VPDS VYQH LVQD RHNE NDSG RELV ITDP |
| Gene ID: | 473 |
| Uniprot: | Q9P2R6 |
| Cellular Location: | Nucleus |
| Calculated MW: | 109kDa/172kDa |
| Observed MW: | 172kDa |
| Synonyms: | RERE, ARG, ARP, ATN1L, DNB1, NEDBEH |
| Background: | This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | RERE: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. A chromosomal aberration involving RERE is found in the neuroblastoma cell line. Translocation t(1;15)(p36.2;q24). 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1p36.23 Molecular Function:poly-glutamine tract binding; protein binding Biological Process: NLS-bearing substrate import into nucleus |
| NCBI Summary: | This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9P2R6 |
| NCBI GenInfo Identifier: | 85540730 |
| NCBI Gene ID: | 473 |
| NCBI Accession: | Q9P2R6.2 |
| UniProt Secondary Accession: | Q9P2R6,O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4 |
| UniProt Related Accession: | Q9P2R6 |
| Molecular Weight: | 109,048 Da |
| NCBI Full Name: | Arginine-glutamic acid dipeptide repeats protein |
| NCBI Synonym Full Names: | arginine-glutamic acid dipeptide repeats |
| NCBI Official Symbol: | RERE |
| NCBI Official Synonym Symbols: | ARG; ARP; DNB1; ATN1L; NEDBEH |
| NCBI Protein Information: | arginine-glutamic acid dipeptide repeats protein |
| UniProt Protein Name: | Arginine-glutamic acid dipeptide repeats protein |
| UniProt Synonym Protein Names: | Atrophin-1-like protein; Atrophin-1-related protein |
| Protein Family: | Arginine-glutamic acid dipeptide repeats protein |
| UniProt Gene Name: | RERE |
| UniProt Entry Name: | RERE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RERE antibody (CAB15255). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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