| UniProt Protein Function: | RBCK1: a E3 ubiquitin-protein ligase that contains a zf-RanBP (Zn-finger in Ran binding protein) and a zf-C3HC4 (RING finger) domain. Phosphorylation apparently reduces its E3 activity. Functions as a transcriptional activator. Its nuclear translocation is prevented by binding to a splice-variant of RBCK1 that lacks the RING finger domain. Interacts with PKCB1, PKCZ, and accepts ubiquitin from E2 ubiquitin-conjugating enzymes including UBE2L3. Interacts with PKCH. Interacts with the HBV pX/HBx protein, which is required to activate transcription of the viral genome. Three splice-variant isoforms of the human protein have been reported. Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytosol Molecular Function: protein binding; ubiquitin binding; ubiquitin-protein ligase activity Biological Process: activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; T cell receptor signaling pathway Disease: Polyglucosan Body Myopathy, Early-onset, With Or Without Immunodeficiency |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BYM8 |
| NCBI GenInfo Identifier: | 166214993 |
| NCBI Gene ID: | 10616 |
| NCBI Accession: | Q9BYM8.2 |
| UniProt Secondary Accession: | Q9BYM8,O95623, Q86SL2, Q96BS3, Q9BYM9 |
| UniProt Related Accession: | Q9BYM8 |
| Molecular Weight: | 25,654 Da |
| NCBI Full Name: | RanBP-type and C3HC4-type zinc finger-containing protein 1 |
| NCBI Synonym Full Names: | RANBP2-type and C3HC4-type zinc finger containing 1 |
| NCBI Official Symbol: | RBCK1 |
| NCBI Official Synonym Symbols: | XAP3; XAP4; HOIL1; PBMEI; PGBM1; RBCK2; RNF54; HOIL-1; ZRANB4; C20orf18; UBCE7IP3 |
| NCBI Protein Information: | ranBP-type and C3HC4-type zinc finger-containing protein 1 |
| UniProt Protein Name: | RanBP-type and C3HC4-type zinc finger-containing protein 1 |
| UniProt Synonym Protein Names: | HBV-associated factor 4; Heme-oxidized IRP2 ubiquitin ligase 1; HOIL-1; Hepatitis B virus X-associated protein 4; RING finger protein 54; RING-type E3 ubiquitin transferase HOIL-1Curated; Ubiquitin-conjugating enzyme 7-interacting protein 3 |
| Protein Family: | |
| UniProt Gene Name: | RBCK1 |
| UniProt Entry Name: | |
