Anti-RASD1 Antibody (CAB15451)
- SKU:
- CAB15451
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-RASD1 Antibody |
| Antibody SKU: | CAB15451 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 132-281 of human RASD1 (NP_057168.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, LO2, 293T, Mouse brain, Mouse heart, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 132-281 of human RASD1 (NP_057168.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TKEN VDVP LVIC GNKG DRDF YREV DQRE IEQL VGDD PQRC AYFE ISAK KNSS LDQM FRAL FAMA KLPS EMSP DLHR KVSV QYCD VLHK KALR NKKL LRAG SGGG GGDP GDAF GIVA PFAR RPSV HSDL MYIR EKAS AGSQ AKDK ERCV IS |
| Gene ID: | 51655 |
| Uniprot: | Q9Y272 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Lipid-anchor, Nucleus, perinuclear region |
| Calculated MW: | 13kDa/31kDa |
| Observed MW: | 31kDa |
| Synonyms: | RASD1, AGS1, DEXRAS1, MGC:26290 |
| Background: | This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | RASD1: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65. Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65. By dexamethasone. Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues. Belongs to the small GTPase superfamily. RasD family. |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein, monomeric, RasD; G protein Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: nucleus; perinuclear region of cytoplasm; plasma membrane; sarcoplasmic reticulum Molecular Function:GTP binding; GTPase activity; protein binding Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of transcription, DNA-dependent; nitric oxide mediated signal transduction; signal transduction; small GTPase mediated signal transduction |
| NCBI Summary: | This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65 which interacts with the Alzheimer's disease amyloid precursor protein (APP). This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have beeen found for this gene. |
| UniProt Code: | Q9Y272 |
| NCBI GenInfo Identifier: | 7706359 |
| NCBI Gene ID: | 51655 |
| NCBI Accession: | NP_057168.1 |
| UniProt Secondary Accession: | Q9Y272,Q9NYB4, B2R709, |
| UniProt Related Accession: | Q9HC43,Q9Y272 |
| Molecular Weight: | 31,642 Da |
| NCBI Full Name: | dexamethasone-induced Ras-related protein 1 isoform 1 proprotein |
| NCBI Synonym Full Names: | RAS, dexamethasone-induced 1 |
| NCBI Official Symbol: | RASD1 |
| NCBI Official Synonym Symbols: | AGS1; DEXRAS1; MGC:26290 |
| NCBI Protein Information: | dexamethasone-induced Ras-related protein 1; OTTHUMP00000065541; ras-related protein; activator of G-protein signaling 1 |
| UniProt Protein Name: | Dexamethasone-induced Ras-related protein 1 |
| UniProt Synonym Protein Names: | Activator of G-protein signaling 1 |
| Protein Family: | Dexamethasone-induced Ras-related protein |
| UniProt Gene Name: | RASD1 |
| UniProt Entry Name: | RASD1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RASD1 antibody (CAB15451) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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