Anti-RANBP9 Antibody (CAB12097)
- SKU:
- CAB12097
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-RANBP9 Antibody |
| Antibody SKU: | CAB12097 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 480-605 of human RANBP9 (NP_005484.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | Raji, A-549, B cells |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 480-605 of human RANBP9 (NP_005484.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PFSS PSMS PSHG MNIH NLAS GKGS TAHF SGFE SCSN GVIS NKAH QSYC HSNK HQSS NLNV PELN SINM SRSQ QVNN FTSN DVDM ETDH YSNG VGET SSNG FLNG SSKH DHEM EDCD TEME VDSS QL |
| Gene ID: | 10048 |
| Uniprot: | Q96S59 |
| Cellular Location: | Cytoplasm, Nucleus, cytosol |
| Calculated MW: | 43kDa/55kDa/77kDa |
| Observed MW: | 100kDa |
| Synonyms: | RANBP9, BPM-L, BPM90, RANBPM, RanBP7 |
| Background: | This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. |
| UniProt Protein Function: | RANBP9: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. Belongs to the RANBP9/10 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Adaptor/scaffold; GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 6p23 Cellular Component: microtubule associated complex; nucleus; cytosol Molecular Function:protein binding; enzyme binding; Ran GTPase binding Biological Process: axon guidance; protein complex assembly; microtubule nucleation |
| NCBI Summary: | This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96S59 |
| NCBI GenInfo Identifier: | 61215334 |
| NCBI Gene ID: | 10048 |
| NCBI Accession: | Q96S59.1 |
| UniProt Related Accession: | Q96S59 |
| Molecular Weight: | 42kDa |
| NCBI Full Name: | Ran-binding protein 9 |
| NCBI Synonym Full Names: | RAN binding protein 9 |
| NCBI Official Symbol: | RANBP9 |
| NCBI Official Synonym Symbols: | BPM-L; BPM90; RANBPM; RanBP7 |
| NCBI Protein Information: | ran-binding protein 9 |
| UniProt Protein Name: | Ran-binding protein 9 |
| UniProt Synonym Protein Names: | BPM-L; BPM90; Ran-binding protein M; RanBPM; RanBP7 |
| Protein Family: | Ran-binding protein |
| UniProt Gene Name: | RANBP9 |
| UniProt Entry Name: | RANB9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RANBP9 antibody (CAB12097) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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