Anti-RALB Antibody (CAB4069)
- SKU:
- CAB4069
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-RALB Antibody |
| Antibody SKU: | CAB4069 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RALB (NP_002872.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, HepG2, Mouse lung, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RALB (NP_002872.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAN KSKG QSSL ALHK VIMV GSGG VGKS ALTL QFMY DEFV EDYE PTKA DSYR KKVV LDGE EVQI DILD TAGQ EDYA AIRD NYFR SGEG FLLV FSIT EHES FTAT AEFR EQIL RVKA EEDK IPLL VVGN KSDL EERR QVPV EEAR SKAE EWGV QYVE TSAK TRAN VDKV FFDL MREI RTKK MSEN KDKN GKKS SKNK KSFK ERCC LL |
| Gene ID: | 5899 |
| Uniprot: | P11234 |
| Cellular Location: | Cell membrane, Cytoplasmic side, Lipid-anchor |
| Calculated MW: | 23kDa/25kDa |
| Observed MW: | 23kDa |
| Synonyms: | RALB |
| Background: | This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. |
| UniProt Protein Function: | RALB: Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. |
| UniProt Protein Details: | Protein type:G protein, monomeric, Ras; G protein; G protein, monomeric Chromosomal Location of Human Ortholog: 2q14.2 Cellular Component: plasma membrane; exocyst; autophagic vacuole; midbody Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; ubiquitin protein ligase binding; ATPase binding Biological Process: regulation of exocyst localization; positive regulation of protein binding; nerve growth factor receptor signaling pathway; apoptosis; metabolic process; regulation of exocyst assembly; Ras protein signal transduction; cytokinesis; positive regulation of protein amino acid phosphorylation; negative regulation of protein binding; signal transduction; cellular response to starvation |
| NCBI Summary: | This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11234 |
| NCBI GenInfo Identifier: | 131835 |
| NCBI Gene ID: | 5899 |
| NCBI Accession: | P11234.1 |
| UniProt Secondary Accession: | P11234,Q53T32, Q6ZS74, B4E040, |
| UniProt Related Accession: | P11234 |
| Molecular Weight: | 206 |
| NCBI Full Name: | Ras-related protein Ral-B |
| NCBI Synonym Full Names: | v-ral simian leukemia viral oncogene homolog B |
| NCBI Official Symbol: | RALB |
| NCBI Protein Information: | ras-related protein Ral-B; RAS-like protein B; ras related GTP binding protein B; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) |
| UniProt Protein Name: | Ras-related protein Ral-B |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RALB |
| UniProt Entry Name: | RALB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RALB antibody (CAB4069) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using RALB antibody (CAB4069) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using RALB antibody (CAB4069) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using RALB antibody (CAB4069) at dilution of 1:100 (40x lens). |
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