| UniProt Protein Function: | MgcRacGAP: a rac GTPase activating protein. Plays an important role in cytokinesis by regulating cortical movement through RhoA. Phosphorylation by Aurora B apparently induces GAP activity toward RhoA. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 12q13.12 Cellular Component: nucleoplasm; microtubule; extrinsic to internal side of plasma membrane; acrosome; spindle midzone; midbody; nucleus; cytosol; cleavage furrow Molecular Function:gamma-tubulin binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; microtubule binding; beta-tubulin binding; protein kinase binding; GTPase activator activity; alpha-tubulin binding Biological Process: positive regulation of cytokinesis; regulation of attachment of spindle microtubules to kinetochore; spindle midzone assembly involved in mitosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; sulfate transport; microtubule-based movement; regulation of small GTPase mediated signal transduction; embryonic development; cytokinesis after mitosis; small GTPase mediated signal transduction; neuroblast proliferation; spermatogenesis; blood coagulation; cytokinesis, contractile ring formation; positive regulation of GTPase activity |
| NCBI Summary: | The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q9H0H5 |
| NCBI GenInfo Identifier: | 74762727 |
| NCBI Gene ID: | 29127 |
| NCBI Accession: | Q9H0H5.1 |
| UniProt Secondary Accession: | Q9H0H5,Q6PJ26, Q9NWN2, Q9P250, Q9P2W2, |
| UniProt Related Accession: | Q9H0H5 |
| Molecular Weight: | 632 |
| NCBI Full Name: | Rac GTPase-activating protein 1 |
| NCBI Synonym Full Names: | Rac GTPase activating protein 1 |
| NCBI Official Symbol: | RACGAP1 |
| NCBI Official Synonym Symbols: | CYK4; ID-GAP; HsCYK-4; MgcRacGAP |
| NCBI Protein Information: | rac GTPase-activating protein 1; RACGAP1; protein CYK4 homolg; protein CYK4 homolog; male germ cell RacGap; GTPase activating protein |
| UniProt Protein Name: | Rac GTPase-activating protein 1 |
| UniProt Synonym Protein Names: | Male germ cell RacGap; MgcRacGAP; Protein CYK4 homolog; CYK4; HsCYK-4 |
| Protein Family: | Rac GTPase-activating protein |
| UniProt Gene Name: | RACGAP1 |
| UniProt Entry Name: | RGAP1_HUMAN |
