Anti-RAB12 Antibody (CAB14320)
- SKU:
- CAB14320
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
| Antibody Name: | Anti-RAB12 Antibody |
| Antibody SKU: | CAB14320 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human RAB12 (NP_001020471.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | NIH/3T3, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human RAB12 (NP_001020471.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDPG AALQ RRAG GGGG LGAG SPAL SGGQ GRRR KQPP RPAD FKLQ VIII GSRG VGKT SLME RFTD DTFC EA |
| Gene ID: | 201475 |
| Uniprot: | Q6IQ22 |
| Cellular Location: | Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Lipid-anchor, Lysosome membrane, Recycling endosome membrane, autophagosome |
| Calculated MW: | 27kDa |
| Observed MW: | 36kDa |
| Synonyms: | RAB12 |
| Background: |
| UniProt Protein Function: | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy. |
| UniProt Code: | Q6IQ22 |
| NCBI GenInfo Identifier: | 106507164 |
| NCBI Gene ID: | 201475 |
| NCBI Accession: | NP_001020471.2 |
| UniProt Secondary Accession: | Q6IQ22,Q4KMQ3, A6NEF5, |
| UniProt Related Accession: | Q6IQ22 |
| Molecular Weight: | 27,248 Da |
| NCBI Full Name: | ras-related protein Rab-12 |
| NCBI Synonym Full Names: | RAB12, member RAS oncogene family |
| NCBI Official Symbol: | RAB12 |
| NCBI Protein Information: | ras-related protein Rab-12 |
| UniProt Protein Name: | Ras-related protein Rab-12 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB12 |
 | Western blot analysis of extracts of various cell lines, using RAB12 antibody (CAB14320) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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