Anti-QK1 Antibody (CAB0193)

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SKU:
CAB0193
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
QKI
Hqk
QK
QK1
QK3
hqkI
protein quaking
Frequently bought together:

Description

Product Name:QK1 Rabbit mAb
Product Code:CAB0193
Size:20uL, 50uL, 100uL
Synonyms:QKI, Hqk, QK, QK1, QK3, hqkI, protein quaking
Applications:WB, IF, IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human QK1.
Applications:WB, IF, IP
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SKOV3, NIH/3T3, U-251MG, Neuro-2a, Mouse brain, Rat brain, Rat heart
Immunogen:A synthesized peptide derived from human QK1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9444
Uniprot:Q96PU8
Cellular Location:Cytoplasm, Nucleus
Calculated MW:38kDa
Observed MW:38KDa/40KDa
UniProt Protein Function:RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
NCBI Summary:The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:Q96PU8
NCBI GenInfo Identifier:74761039
NCBI Gene ID:9444
NCBI Accession:Q96PU8.1
UniProt Secondary Accession:Q96PU8,Q2I375, Q5MJQ1, Q969L9, Q96EJ3, Q96KA3, Q96PU6 Q96PU7, Q9P0X6, Q9P0X7, Q9P0X8, Q9P0X9,
UniProt Related Accession:Q96PU8
Molecular Weight:35,131 Da
NCBI Full Name:Protein quaking
NCBI Synonym Full Names:QKI, KH domain containing RNA binding
NCBI Official Symbol:QKI  
NCBI Official Synonym Symbols:QK; Hqk; QK1; QK3; hqkI  
NCBI Protein Information:protein quaking
UniProt Protein Name:Protein quaking
Protein Family:Protein quaking
UniProt Gene Name:QKI  
UniProt Entry Name:QKI_HUMAN

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