Anti-PURB Antibody (CAB18166)
- SKU:
- CAB18166
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-PURB Antibody |
| Antibody SKU: | CAB18166 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human PURB. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LO2, HeLa |
| Immunogen: | Recombinant protein of human PURB. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5814 |
| Uniprot: | Q96QR8 |
| Cellular Location: | |
| Calculated MW: | 33kDa |
| Observed MW: | 38kDa |
 | Western blot - PURB Polyclonal Antibody (CAB18166) |
| Synonyms: | PURB, PURBETA |
| Background: | This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. |
| UniProt Protein Function: | Pur-beta: Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs. Belongs to the PUR DNA-binding protein family. |
| UniProt Protein Details: | Protein type:RNA-binding; DNA-binding Chromosomal Location of Human Ortholog: 7p13 Cellular Component: DNA replication factor A complex; nucleus Molecular Function:mRNA binding; single-stranded DNA binding; transcription factor binding |
| NCBI Summary: | This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96QR8 |
| NCBI GenInfo Identifier: | 74732688 |
| NCBI Gene ID: | 5814 |
| NCBI Accession: | Q96QR8.3 |
| UniProt Secondary Accession: | Q96QR8,A4D2L7, |
| UniProt Related Accession: | Q96QR8 |
| Molecular Weight: | 33,241 Da |
| NCBI Full Name: | Transcriptional activator protein Pur-beta |
| NCBI Synonym Full Names: | purine rich element binding protein B |
| NCBI Official Symbol: | PURB |
| NCBI Official Synonym Symbols: | PURBETA |
| NCBI Protein Information: | transcriptional activator protein Pur-beta |
| UniProt Protein Name: | Transcriptional activator protein Pur-beta |
| UniProt Synonym Protein Names: | Purine-rich element-binding protein B |
| Protein Family: | Transcriptional activator protein |
| UniProt Gene Name: | PURB |
| UniProt Entry Name: | PURB_HUMAN |
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