Anti-PTX3 Antibody (CAB12670)

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SKU:
CAB12670
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
Frequently bought together:

Description

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Antibody Name:Anti-PTX3 Antibody
Antibody SKU:CAB12670
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-240 of human PTX3 (NP_002843.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-240 of human PTX3 (NP_002843.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ENSD DYDL MYVN LDNE IDNG LHPT EDPT PCAC GQEH SEWD KLFI MLEN SQMR ERML LQAT DDVL RGEL QRLR EELG RLAE SLAR PCAP GAPA EARL TSAL DELL QATR DAGR RLAR MEGA EAQR PEEA GRAL AAVL EELR QTRA DLHA VQGW AARS WLPA GCET AILF PMRS KKIF GSVH PVRP MRLE SFSA CIWV KATD VLNK TILF SYGT KRNP YEIQ LYL
Gene ID:5806
Uniprot:P26022
Cellular Location:Secreted
Calculated MW:41kDa
Observed MW:42kDa
Synonyms:PTX3, TNFAIP5, TSG-14
Background:This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions.
UniProt Protein Function:PTX3: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q25

Cellular Component: extracellular space; extracellular region

Molecular Function:complement component C1q binding; zymosan binding; virion binding

Biological Process: positive regulation of nitric oxide biosynthetic process; negative regulation of virion penetration into host cell; positive regulation of phagocytosis; innate immune response; response to yeast; opsonization; inflammatory response

UniProt Code:P26022
NCBI GenInfo Identifier:296452984
NCBI Gene ID:5806
NCBI Accession:P26022.3
UniProt Secondary Accession:P26022,Q38M82, B2R6T6,
UniProt Related Accession:P26022
Molecular Weight:41,976 Da
NCBI Full Name:Pentraxin-related protein PTX3
NCBI Synonym Full Names:pentraxin 3, long
NCBI Official Symbol:PTX3  
NCBI Official Synonym Symbols:TSG-14; TNFAIP5  
NCBI Protein Information:pentraxin-related protein PTX3; pentraxin-3; TNF alpha-induced protein 5; pentaxin-related protein PTX3; tumor necrosis factor alpha-induced protein 5; tumor necrosis factor, alpha-induced protein 5; tumor necrosis factor-inducible protein TSG-14; tumor necrosis factor-inducible gene 14 protein; pentraxin-related gene, rapidly induced by IL-1 beta; pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5
UniProt Protein Name:Pentraxin-related protein PTX3
UniProt Synonym Protein Names:Pentaxin-related protein PTX3; Tumor necrosis factor alpha-induced protein 5; TNF alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; TSG-14
Protein Family:Pentraxin-related protein
UniProt Gene Name:PTX3  
UniProt Entry Name:PTX3_HUMAN
Anti-PTX3 Antibody (CAB12670)Western blot analysis of extracts of mouse liver, using PTX3 antibody (CAB12670) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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