Anti-PTPRU Antibody (CAB8475)

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SKU:
CAB8475
Product type:
Antibody
Application:
WB
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-PTPRU Antibody
Antibody SKU:CAB8475
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1184-1433 of human PTPRU (NP_001181930.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1184-1433 of human PTPRU (NP_001181930.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IALL PRNR DKNR SMDV LPPD RCLP FLIS TDGD SNNY INAA LTDS YTRS AAFI VTLH PLQS TTPD FWRL VYDY GCTS IVML NQLN QSNS AWPC LQYW PEPG RQQY GLME VEFM SGTA DEDL VARV FRVQ NISR LQEG HLLV RHFQ FLRW SAYR DTPD SKKA FLHL LAEV DKWQ AESG DGRT IVHC LNGG GRSG TFCA CATV LEMI RCHN LVDV FFAA KTLR NYKP NMVE TMDQ YHFC YDVA LEYL EGLE SR
Gene ID:10076
Uniprot:Q92729
Cellular Location:Cell junction, Cell membrane, Single-pass type I membrane protein
Calculated MW:160kDa/161kDa/162kDa
Observed MW:180kDa
Synonyms:PTPRU, FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, R-PTP-U, hPTP-J
Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.
UniProt Protein Function:PTPRU: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor protein phosphatase, tyrosine; EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p35.3

Cellular Component: integral to plasma membrane; plasma membrane; intercellular junction

Molecular Function:protein binding; beta-catenin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: negative regulation of cell proliferation; organ regeneration; cell-cell adhesion; homotypic cell-cell adhesion; response to glucocorticoid stimulus; Wnt receptor signaling pathway through beta-catenin; cell differentiation; protein amino acid dephosphorylation; cell adhesion; transmembrane receptor protein tyrosine phosphatase signaling pathway; negative regulation of cell migration

NCBI Summary:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]
UniProt Code:Q92729
NCBI GenInfo Identifier:229462800
NCBI Gene ID:10076
NCBI Accession:Q92729.2
UniProt Secondary Accession:Q92729,O00197, P78399, Q59HA4, Q5SYU4, Q5SYU5, Q92735 Q92850, A6H8L1,
UniProt Related Accession:Q92729
Molecular Weight:161,648 Da
NCBI Full Name:Receptor-type tyrosine-protein phosphatase U
NCBI Synonym Full Names:protein tyrosine phosphatase, receptor type, U
NCBI Official Symbol:PTPRU  
NCBI Official Synonym Symbols:FMI; PTP; PCP-2; PTP-J; PTPRO; PTPU2; PTP-PI; PTP-RO; PTPPSI; hPTP-J; R-PTP-U; R-PTP-PSI  
NCBI Protein Information:receptor-type tyrosine-protein phosphatase U; PTP pi; pi R-PTP-Psi; protein-tyrosine phosphatase J; protein-tyrosine phosphatase pi; pancreatic carcinoma phosphatase 2; Receptor protein tyrosine phosphatase hPTP-J; protein-tyrosine phosphatase receptor omicron; receptor-type protein-tyrosine phosphatase psi
UniProt Protein Name:Receptor-type tyrosine-protein phosphatase U
UniProt Synonym Protein Names:Pancreatic carcinoma phosphatase 2; PCP-2; Protein-tyrosine phosphatase J; PTP-J; hPTP-J; Protein-tyrosine phosphatase pi; PTP pi; Protein-tyrosine phosphatase receptor omicron; PTP-RO; Receptor-type protein-tyrosine phosphatase psi; R-PTP-psi
Protein Family:Receptor-type tyrosine-protein phosphatase
UniProt Gene Name:PTPRU  
UniProt Entry Name:PTPRU_HUMAN

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