Anti-PTPRD Antibody (CAB8559)
- SKU:
- CAB8559
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PTPRD Antibody |
| Antibody SKU: | CAB8559 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 475-574 of human PTPRD (NP_002830.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-1080, DU145, B cells, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 475-574 of human PTPRD (NP_002830.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QITT IGNL VPQK TYSV KVLA FTSI GDGP LSSD IQVI TQTG VPGQ PLNF KAEP ESET SILL SWTP PRSD TIAN YELV YKDG EHGE EQRI TIEP GTSY RLQG |
| Gene ID: | 5789 |
| Uniprot: | P23468 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 156kDa/169kDa/212kDa/214kDa |
| Observed MW: | 180-215kDa |
| Synonyms: | PTPRD, HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA |
| Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P23468 |
| NCBI GenInfo Identifier: | 1709906 |
| NCBI Gene ID: | 5789 |
| NCBI Accession: | P23468.2 |
| UniProt Secondary Accession: | P23468,Q3KPJ0, Q3KPJ1, Q3KPJ2, B1ALA0, F5GWT7, |
| UniProt Related Accession: | P23468 |
| Molecular Weight: | 169,277 Da |
| NCBI Full Name: | Receptor-type tyrosine-protein phosphatase delta |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type D |
| NCBI Official Symbol: | PTPRD |
| NCBI Official Synonym Symbols: | HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase delta |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase delta |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRD |
| UniProt Entry Name: | PTPRD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTPRD Antibody (CAB8559) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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