Anti-PTGR1 Antibody (CAB4521)
- SKU:
- CAB4521
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PTGR1
- LTB4DH
- PGR1
- ZADH3
Frequently bought together:
Description
| Product Name: | PTGR1 Rabbit pAb |
| Product Code: | CAB4521 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PTGR1, LTB4DH, PGR1, ZADH3 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human PTGR1 (NP_036344.2). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse heart, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human PTGR1 (NP_036344.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVRT KTWT LKKH FVGY PTNS DFEL KTAE LPPL KNGE VLLE ALFL TVDP YMRV AAKR LKEG DTMM GQQV AKVV ESKN VALP KGTI VLAS PGWT THSI SDGK DLEK LLTE WPDT IPL |
| Gene ID: | 22949 |
| Uniprot: | Q14914 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 32kDa/35kDa |
| Observed MW: | 36kDa |
| UniProt Protein Function: | LTB4DH: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. Belongs to the NADP-dependent oxidoreductase L4BD family. |
| UniProt Protein Details: | Protein type:EC 1.3.1.48; Oxidoreductase; EC 1.3.1.74 Chromosomal Location of Human Ortholog: 9q31.3 Cellular Component: cytoplasm Molecular Function:15-oxoprostaglandin 13-oxidase activity; zinc ion binding; 2-alkenal reductase activity Biological Process: response to toxin; cyclooxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process |
| NCBI Summary: | This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q14914 |
| NCBI GenInfo Identifier: | 23503081 |
| NCBI Gene ID: | 22949 |
| NCBI Accession: | Q14914.2 |
| UniProt Secondary Accession: | Q14914,Q8IYQ0, Q9H1X6, A8K0N2, B4DPK3, F5GY50, |
| UniProt Related Accession: | Q14914 |
| Molecular Weight: | 329 |
| NCBI Full Name: | Prostaglandin reductase 1 |
| NCBI Synonym Full Names: | prostaglandin reductase 1 |
| NCBI Official Symbol: | PTGR1 |
| NCBI Official Synonym Symbols: | PGR1; ZADH3; LTB4DH |
| NCBI Protein Information: | prostaglandin reductase 1; PRG-1; 15-oxoprostaglandin 13-reductase; leukotriene B4 12-hydroxydehydrogenase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; zinc binding alcohol dehydrogenase domain containing 3 |
| UniProt Protein Name: | Prostaglandin reductase 1 |
| UniProt Synonym Protein Names: | 15-oxoprostaglandin 13-reductase (EC:1.3.1.48); NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC:1.3.1.74) |
| Protein Family: | Prostaglandin reductase |
| UniProt Gene Name: | PTGR1 |
| UniProt Entry Name: | PTGR1_HUMAN |
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