Anti-PTGES2 Antibody (CAB7137)
- SKU:
- CAB7137
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-PTGES2 Antibody |
| Antibody SKU: | CAB7137 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 88-377 of human PTGES2 (NP_079348.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse kidney, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 88-377 of human PTGES2 (NP_079348.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ERSA AQLS LSSR LQLT LYQY KTCP FCSK VRAF LDFH ALPY QVVE VNPV RRAE IKFS SYRK VPIL VAQE GESS QQLN DSSV IISA LKTY LVSG QPLE EIIT YYPA MKAV NEQG KEVT EFGN KYWL MLNE KEAQ QVYG GKEA RTEE MKWR QWAD DWLV HLIS PNVY RTPT EALA SFDY IVRE GKFG AVEG AVAK YMGA AAMY LISK RLKS RHRL QDNV REDL YEAA DKWV AAVG KDRP FMGG QKPN LADL AVYG VLRV MEGL DAFD DLMQ HTHI QPWY LRVE RAIT EASP AH |
| Gene ID: | 80142 |
| Uniprot: | Q9H7Z7 |
| Cellular Location: | Cytoplasm, Golgi apparatus membrane, Single-pass membrane protein, perinuclear region |
| Calculated MW: | 41kDa |
| Observed MW: | 35KDa |
| Synonyms: | PTGES2, C9orf15, GBF-1, GBF1, PGES2, mPGES-2 |
| Background: | The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. |
| UniProt Protein Function: | PTGES2: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. Belongs to the GST superfamily. |
| UniProt Protein Details: | Protein type:Isomerase; EC 5.3.99.3; Lipid Metabolism - arachidonic acid; Membrane protein, integral Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: Golgi membrane; mitochondrion; perinuclear region of cytoplasm; integral to membrane; cytosol; nucleus Molecular Function:DNA binding; glutathione binding; electron carrier activity; lyase activity; heme binding; protein disulfide oxidoreductase activity; prostaglandin-E synthase activity Biological Process: secretion; cell redox homeostasis; positive regulation of transcription, DNA-dependent; prostaglandin biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009] |
| UniProt Code: | Q9H7Z7 |
| NCBI GenInfo Identifier: | 73921741 |
| NCBI Gene ID: | 80142 |
| NCBI Accession: | Q9H7Z7.1 |
| UniProt Secondary Accession: | Q9H7Z7,Q53EW9, Q5SYV6, Q96GI0, Q96GL2, |
| UniProt Related Accession: | Q9H7Z7 |
| Molecular Weight: | |
| NCBI Full Name: | Prostaglandin E synthase 2 |
| NCBI Synonym Full Names: | prostaglandin E synthase 2 |
| NCBI Official Symbol: | PTGES2 |
| NCBI Official Synonym Symbols: | GBF1; GBF-1; PGES2; C9orf15; mPGES-2 |
| NCBI Protein Information: | prostaglandin E synthase 2; GATE-binding factor 1; gamma-interferon-activated transcriptional element-binding factor 1; mPGE synthase-2; membrane-associated prostaglandin E synthase 2; membrane-associated prostaglandin E synthase-2; microsomal prostaglandin E synthase-2; prostaglandin-H(2) E-isomerase |
| UniProt Protein Name: | Prostaglandin E synthase 2 |
| UniProt Synonym Protein Names: | Membrane-associated prostaglandin E synthase-2 |
| UniProt Gene Name: | PTGES2 |
| UniProt Entry Name: | PGES2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTGES2 Rabbit pAb (CAB7137) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using PTGES2 antibody (CAB7137) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human kidney cancer using PTGES2 antibody (CAB7137) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using PTGES2 antibody (CAB7137) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A-549 cells using PTGES2 antibody (CAB7137). Blue: DAPI for nuclear staining. |
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