Anti-PTGES2 Antibody (CAB13440)

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SKU:
CAB13440
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-PTGES2 Antibody
Antibody SKU:CAB13440
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 88-377 of human PTGES2 (NP_079348.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HeLa, BT-474, HL-60, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 88-377 of human PTGES2 (NP_079348.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ERSA AQLS LSSR LQLT LYQY KTCP FCSK VRAF LDFH ALPY QVVE VNPV RRAE IKFS SYRK VPIL VAQE GESS QQLN DSSV IISA LKTY LVSG QPLE EIIT YYPA MKAV NEQG KEVT EFGN KYWL MLNE KEAQ QVYG GKEA RTEE MKWR QWAD DWLV HLIS PNVY RTPT EALA SFDY IVRE GKFG AVEG AVAK YMGA AAMY LISK RLKS RHRL QDNV REDL YEAA DKWV AAVG KDRP FMGG QKPN LADL AVYG VLRV MEGL DAFD DLMQ HTHI QPWY LRVE RAIT EASP AH
Gene ID:80142
Uniprot:Q9H7Z7
Cellular Location:Cytoplasm, Golgi apparatus membrane, Single-pass membrane protein, perinuclear region
Calculated MW:41kDa
Observed MW:34kDa
Synonyms:PTGES2, C9orf15, GBF-1, GBF1, PGES2, mPGES-2
Background:The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene.
UniProt Protein Function:PTGES2: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. Belongs to the GST superfamily.
UniProt Protein Details:

Protein type:Isomerase; EC 5.3.99.3; Lipid Metabolism - arachidonic acid; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: Golgi membrane; mitochondrion; perinuclear region of cytoplasm; integral to membrane; cytosol; nucleus

Molecular Function:DNA binding; glutathione binding; electron carrier activity; lyase activity; heme binding; protein disulfide oxidoreductase activity; prostaglandin-E synthase activity

Biological Process: secretion; cell redox homeostasis; positive regulation of transcription, DNA-dependent; prostaglandin biosynthetic process

NCBI Summary:The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
UniProt Code:Q9H7Z7
NCBI GenInfo Identifier:73921741
NCBI Gene ID:80142
NCBI Accession:Q9H7Z7.1
UniProt Secondary Accession:Q9H7Z7,Q53EW9, Q5SYV6, Q96GI0, Q96GL2,
UniProt Related Accession:Q9H7Z7
Molecular Weight:
NCBI Full Name:Prostaglandin E synthase 2
NCBI Synonym Full Names:prostaglandin E synthase 2
NCBI Official Symbol:PTGES2  
NCBI Official Synonym Symbols:GBF1; GBF-1; PGES2; C9orf15; mPGES-2  
NCBI Protein Information:prostaglandin E synthase 2; GATE-binding factor 1; gamma-interferon-activated transcriptional element-binding factor 1; mPGE synthase-2; membrane-associated prostaglandin E synthase 2; membrane-associated prostaglandin E synthase-2; microsomal prostaglandin E synthase-2; prostaglandin-H(2) E-isomerase
UniProt Protein Name:Prostaglandin E synthase 2
UniProt Synonym Protein Names:Membrane-associated prostaglandin E synthase-2
UniProt Gene Name:PTGES2  
UniProt Entry Name:PGES2_HUMAN
Anti-PTGES2 Antibody (CAB13440)Western blot analysis of extracts of various cell lines, using PTGES2 antibody (CAB13440) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-PTGES2 Antibody (CAB13440)Immunofluorescence analysis of A549 cells using PTGES2 antibody (CAB13440). Blue: DAPI for nuclear staining.

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