Anti-PSMA/FOLH1 Antibody (CAB9547)
- SKU:
- CAB9547
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- FGCP
- FOLH
- GCP2
- GCPII
- NAALAD1
- NAALAdase
- PSM
- PSMA
- mGCP
Frequently bought together:
Description
| Product Name: | PSMA/FOLH1 Rabbit mAb |
| Product Code: | CAB9547 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP |
| Applications: | WB, IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PSMA/FOLH1 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | LNCaP |
| Immunogen: | A synthesized peptide derived from human PSMA/FOLH1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2346 |
| Uniprot: | Q04609 |
| Calculated MW: | 110kDa |
| Observed MW: | 100KDa |
| UniProt Protein Function: | FOLH1: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Belongs to the peptidase M28 family. M28B subfamily. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.17.21; Protease Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: membrane; integral to plasma membrane; cytoplasm Molecular Function:peptidase activity; dipeptidase activity; metallopeptidase activity; carboxypeptidase activity; metal ion binding Biological Process: folic acid and derivative metabolic process; proteolysis |
| NCBI Summary: | This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q04609 |
| NCBI GenInfo Identifier: | 548615 |
| NCBI Gene ID: | 2346 |
| NCBI Accession: | Q04609.1 |
| UniProt Secondary Accession: | Q04609,O43748, Q16305, Q541A4, Q8TAY3, Q9NP15, A4UU12 A9CB79, B7Z312, B7Z343, D3DQS5, E9PDX8, |
| UniProt Related Accession: | Q04609 |
| Molecular Weight: | 84kDa |
| NCBI Full Name: | Glutamate carboxypeptidase 2 |
| NCBI Synonym Full Names: | folate hydrolase (prostate-specific membrane antigen) 1 |
| NCBI Official Symbol: | FOLH1 |
| NCBI Official Synonym Symbols: | PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase |
| NCBI Protein Information: | glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen |
| UniProt Protein Name: | Glutamate carboxypeptidase 2 |
| UniProt Synonym Protein Names: | Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; PSM; PSMA; Pteroylpoly-gamma-glutamate carboxypeptidase |
| UniProt Gene Name: | FOLH1 |
| UniProt Entry Name: | FOLH1_HUMAN |
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