Anti-PRODH Antibody (CAB5836)
- SKU:
- CAB5836
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-PRODH Antibody |
| Antibody SKU: | CAB5836 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 321-600 of human PRODH (NP_057419.4). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse kidney, Mouse heart, Rat liver, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 321-600 of human PRODH (NP_057419.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IDSR TKLS KHLV VPNA QTGQ LEPL LSRF TEEE ELQM TRML QRMD VLAK KATE MGVR LMVD AEQT YFQP AISR LTLE MQRK FNVE KPLI FNTY QCYL KDAY DNVT LDVE LARR EGWC FGAK LVRG AYLA QERA RAAE IGYE DPIN PTYE ATNA MYHR CLDY VLEE LKHN AKAK VMVA SHNE DTVR FALR RMEE LGLH PADH QVYF GQLL GMCD QISF PLGQ AGYP VYKY VPYG PVME VLPY LSRR ALEN SSLM KGTH RERQ LLWL ELLR RLRT GNLF HRPA |
| Gene ID: | 5625 |
| Uniprot: | O43272 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 56kDa/59kDa/68kDa |
| Observed MW: | 68kDa |
| Synonyms: | PRODH, HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6 |
| Background: | This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PRODH: Converts proline to delta-1-pyrroline-5-carboxylate. Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1). HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome. Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Belongs to the proline oxidase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.5.5.2; Mitochondrial; Amino Acid Metabolism - arginine and proline; Oxidoreductase Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: mitochondrial matrix; mitochondrial inner membrane Molecular Function:proline dehydrogenase activity Biological Process: proline catabolic process; 4-hydroxyproline catabolic process; induction of apoptosis by oxidative stress; proline catabolic process to glutamate; proline metabolic process Disease: Hyperprolinemia, Type I; Schizophrenia 4 |
| NCBI Summary: | This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010] |
| UniProt Code: | O43272 |
| NCBI GenInfo Identifier: | 327478561 |
| NCBI Gene ID: | 5625 |
| NCBI Accession: | O43272.3 |
| UniProt Secondary Accession: | O43272,O14680, Q0P507, Q147W8, Q504W1, Q59FI8, Q6NV86 Q9UF13, A6NF53, |
| UniProt Related Accession: | O43272 |
| Molecular Weight: | 600 |
| NCBI Full Name: | Proline dehydrogenase 1, mitochondrial |
| NCBI Synonym Full Names: | proline dehydrogenase (oxidase) 1 |
| NCBI Official Symbol: | PRODH |
| NCBI Official Synonym Symbols: | POX; PIG6; HSPOX2; PRODH1; PRODH2; TP53I6 |
| NCBI Protein Information: | proline dehydrogenase 1, mitochondrial; proline oxidase 2; p53-induced gene 6 protein; proline oxidase, mitochondrial; tumor protein p53 inducible protein 6 |
| UniProt Protein Name: | Proline dehydrogenase 1, mitochondrial |
| UniProt Synonym Protein Names: | Proline oxidase; Proline oxidase 2; p53-induced gene 6 protein |
| UniProt Gene Name: | PRODH |
| UniProt Entry Name: | PROD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PRODH antibody (CAB5836) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Mouse IgG (H+L) (CABS003) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using PRODH antibody (CAB5836) at dilution of 1:100 (40x lens). |
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