Anti-PREX1 Antibody (CAB18344)

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SKU:
CAB18344
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Frequently bought together:

Description

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Antibody Name:Anti-PREX1 Antibody
Antibody SKU:CAB18344
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human PREX1.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant protein of human PREX1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:57580
Uniprot:Q8TCU6
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:P-REX1, PREX1
Background:
UniProt Protein Function:PREX1: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Interacts preferentially with RAC2. Interacts with RAC1. Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: cytoplasm; cytosol; dendritic shaft; growth cone; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane

Molecular Function:enzyme binding; GTPase activator activity; phospholipid binding; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: actin filament polymerization; G-protein coupled receptor protein signaling pathway; neutrophil activation; neutrophil chemotaxis; positive regulation of GTPase activity; regulation of actin filament polymerization; regulation of dendrite development; regulation of Rho protein signal transduction; superoxide metabolic process; T cell differentiation

NCBI Summary:The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TCU6
NCBI GenInfo Identifier:148886999
NCBI Gene ID:57580
NCBI Accession:Q8TCU6.3
UniProt Secondary Accession:Q8TCU6,Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55 Q9H4Q6, Q9P2D2, Q9UGQ4, E1P5X9,
UniProt Related Accession:Q8TCU6
Molecular Weight:175,847 Da
NCBI Full Name:Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
NCBI Synonym Full Names:phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
NCBI Official Symbol:PREX1  
NCBI Official Synonym Symbols:P-REX1  
NCBI Protein Information:phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
UniProt Protein Name:Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Protein Family:Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
UniProt Gene Name:PREX1  
UniProt Entry Name:PREX1_HUMAN

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