Anti-PRDX2 Antibody (CAB1919)[KO Validated]

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SKU:
CAB1919
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-PRDX2 Antibody [KO Validated]
Antibody SKU:CAB1919
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human PRDX2 (NP_859428.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:SW480, 22Rv1, HepG2, K-562, BT-474, Mouse brain, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human PRDX2 (NP_859428.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASG NARI GKPA PDFK ATAV VDGA FKEV KLSD YKGK YVVL FFYP LDFT FVCP TEII AFSN RAED FRKL GCEV LGVS VDSQ FTHL AWYE QGPK REVA AKLT PSGP SSVA SWPL LNLW NLRF PIVK IMET LPPK SLRM MTVI SI
Gene ID:7001
Uniprot:P32119
Cellular Location:Cytoplasm
Calculated MW:15kDa/21kDa
Observed MW:20kDa
Synonyms:PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA
Background:This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13.
UniProt Protein Function:PRDX2: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Three splice-variant isoforms have been identified.
UniProt Protein Details:

Protein type:Oxidoreductase; EC 1.11.1.15

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; cytosol

Molecular Function:antioxidant activity; thioredoxin peroxidase activity

Biological Process: regulation of apoptosis; response to reactive oxygen species; removal of superoxide radicals; hydrogen peroxide catabolic process; response to oxidative stress; negative regulation of neuron apoptosis; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
UniProt Code:P32119
NCBI GenInfo Identifier:2507169
NCBI Gene ID:7001
NCBI Accession:P32119.5
UniProt Secondary Accession:P32119,P31945, P32118, P35701, Q6FHG4, Q92763, Q9UC23 A8K0C0,
UniProt Related Accession:P32119
Molecular Weight:198
NCBI Full Name:Peroxiredoxin-2
NCBI Synonym Full Names:peroxiredoxin 2
NCBI Official Symbol:PRDX2  
NCBI Official Synonym Symbols:PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a  
NCBI Protein Information:peroxiredoxin-2; torin; thioredoxin peroxidase 1; thiol-specific antioxidant 1; natural killer cell-enhancing factor B; thioredoxin-dependent peroxide reductase 1; epididymis secretory sperm binding protein Li 2a
UniProt Protein Name:Peroxiredoxin-2
UniProt Synonym Protein Names:Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1
Protein Family:Peroxiredoxin
UniProt Gene Name:PRDX2  
UniProt Entry Name:PRDX2_HUMAN
Anti-PRDX2 Antibody [KO Validated] (CAB1919)Western blot analysis of extracts of various cell lines, using PRDX2 antibody (CAB1919) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-PRDX2 Antibody [KO Validated] (CAB1919)Western blot analysis of extracts from normal (control) and PRDX2 knockout (KO) 293T cells, using PRDX2 antibody (CAB1919) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-PRDX2 Antibody [KO Validated] (CAB1919)Immunofluorescence analysis of HeLa cells using PRDX2 antibody (CAB1919).

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