Anti-PPT2 Antibody (CAB12251)
- SKU:
- CAB12251
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PPT2 Antibody |
| Antibody SKU: | CAB12251 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-302 of human PPT2 (NP_005146.4). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-302 of human PPT2 (NP_005146.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APAP HRAS YKPV IVVH GLFD SSYS FRHL LEYI NETH PGTV VTVL DLFD GRES LRPL WEQV QGFR EAVV PIMA KAPQ GVHL ICYS QGGL VCRA LLSV MDDH NVDS FISL SSPQ MGQY GDTD YLKW LFPT SMRS NLYR ICYS PWGQ EFSI CNYW HDPH HDDL YLNA SSFL ALIN GERD HPNA TVWR KNFL RVGH LVLI GGPD DGVI TPWQ SSFF GFYD ANET VLEM EEQL VYLR DSFG LKTL LARG AIVR CPMA GISH TAWH SNRT LYET CIEP WLS |
| Gene ID: | 9374 |
| Uniprot: | Q9UMR5 |
| Cellular Location: | Lysosome |
| Calculated MW: | 34kDa |
| Observed MW: | 36kDa |
| Synonyms: | PPT2, C6orf8, G14, PPT-2 |
| Background: | This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. |
| UniProt Protein Function: | PPT2: Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. Belongs to the palmitoyl-protein thioesterase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.2.-; Hydrolase; Lipid Metabolism - fatty acid elongation in mitochondria Chromosomal Location of Human Ortholog: 6p21.32 Cellular Component: lysosomal lumen |
| NCBI Summary: | This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q9UMR5 |
| NCBI GenInfo Identifier: | 296453016 |
| NCBI Gene ID: | 9374 |
| NCBI Accession: | Q9UMR5.4 |
| UniProt Secondary Accession: | Q9UMR5,O14799, Q0P6K0, A2ABC9, A2ABD1, A2ARM7, A2BFH7 A2BFH9, A2BFI2, A8K9L4, B0S868, G8JLE1, |
| UniProt Related Accession: | Q9UMR5 |
| Molecular Weight: | 34kDa |
| NCBI Full Name: | Lysosomal thioesterase PPT2 |
| NCBI Synonym Full Names: | palmitoyl-protein thioesterase 2 |
| NCBI Official Symbol: | PPT2 |
| NCBI Official Synonym Symbols: | G14; PPT-2; C6orf8 |
| NCBI Protein Information: | lysosomal thioesterase PPT2 |
| UniProt Protein Name: | Lysosomal thioesterase PPT2 |
| UniProt Synonym Protein Names: | S-thioesterase G14 |
| Protein Family: | Phosphoenolpyruvate/phosphate translocator |
| UniProt Gene Name: | PPT2 |
 | Western blot analysis of extracts of mouse liver, using PPT2 antibody (CAB12251) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse heart using PPT2 antibody (CAB12251) at dilution of 1:100 (40x lens). |
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