Anti-PPP1R3B Antibody (CAB14931)
- SKU:
- CAB14931
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-PPP1R3B Antibody |
| Antibody SKU: | CAB14931 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human PPP1R3B (NP_078883.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse heart, Rat brain, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human PPP1R3B (NP_078883.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMAV DIEY RYNC MAPS LRQE RFAF KISP KPSK PLRP CIQL SSKN EASG MVAP AVQE KKVK KRVS FADN QGLA LTMV KVFS EFDD PLDM PFNI TELL DNIV SLTT AESE SFVL DFSQ PSAD YLDF RNRL QADH VCLE NCVL |
| Gene ID: | 79660 |
| Uniprot: | Q86XI6 |
| Cellular Location: | |
| Calculated MW: | 32kDa |
| Observed MW: | 33kDa |
| Synonyms: | PPP1R3B, GL, PPP1R4, PTG |
| Background: | This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein. |
| UniProt Protein Function: | PPP1R3B: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes. |
| UniProt Protein Details: | Protein type:Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 8p23.1 Biological Process: regulation of glycogen catabolic process |
| NCBI Summary: | This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011] |
| UniProt Code: | Q86XI6 |
| NCBI GenInfo Identifier: | 74727837 |
| NCBI Gene ID: | 79660 |
| NCBI Accession: | Q86XI6.1 |
| UniProt Secondary Accession: | Q86XI6,Q9H812, B3KTV3, |
| UniProt Related Accession: | Q86XI6 |
| Molecular Weight: | 32,695 Da |
| NCBI Full Name: | Protein phosphatase 1 regulatory subunit 3B |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory subunit 3B |
| NCBI Official Symbol: | PPP1R3B |
| NCBI Official Synonym Symbols: | GL; PTG; PPP1R4 |
| NCBI Protein Information: | protein phosphatase 1 regulatory subunit 3B |
| UniProt Protein Name: | Protein phosphatase 1 regulatory subunit 3B |
| UniProt Synonym Protein Names: | Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Protein phosphatase 1 regulatory subunit 4; PP1 subunit R4; Protein phosphatase 1 subunit GL; PTG |
| Protein Family: | Protein phosphatase 1 regulatory |
| UniProt Gene Name: | PPP1R3B |
| UniProt Entry Name: | PPR3B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPP1R3B antibody (CAB14931) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15s. |
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
Anti-SLC20A2 Antibody (CAB6739)
