Anti-PPP1R13L Antibody (CAB10462)
- SKU:
- CAB10462
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-PPP1R13L Antibody |
| Antibody SKU: | CAB10462 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 589-828 of human PPP1R13L (NP_006654.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, SW480, U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 589-828 of human PPP1R13L (NP_006654.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PPPA PSQS SPPE QPQS MEMR SVLR KAGS PRKA RRAR LNPL VLLL DAAL TGEL EVVQ QAVK EMND PSQP NEEG ITAL HNAI CGAN YSIV DFLI TAGA NVNS PDSH GWTP LHCA ASCN DTVI CMAL VQHG AAIF ATTL SDGA TAFE KCDP YREG YADC ATYL ADVE QSMG LMNS GAVY ALWD YSAE FGDE LSFR EGES VTVL RRDG PEET DWWW AALH GQEG YVPR NYFG LFPR VKPQ RSKV |
| Gene ID: | 10848 |
| Uniprot: | Q8WUF5 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 89kDa |
| Observed MW: | 105kDa |
| Synonyms: | PPP1R13L, IASPP, NKIP1, RAI, RAI4 |
| Background: |
| UniProt Protein Function: | PPP1R13L: an oncoprotein that interacts with and inhibits NF-kappaB, Sp1 and p53. Plays a central role in regulation of apoptosis and transcription. May inhibit p53 by preventing its association with ASPP1 or ASPP2, thereby suppressing the subsequent activation of apoptosis. Required for neuronal survival after axonal injury. Two alternatively spliced isoforms have been described. Isoform 1 is preferrentially found in the cytoplasm; isoform 2 is nuclear. |
| UniProt Protein Details: | Protein type:Phosphatase, regulatory subunit; Apoptosis; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: intercellular bridge; cytoplasm; cell junction; nucleus Molecular Function:identical protein binding; protein binding; transcription corepressor activity; transcription factor binding Biological Process: transcription, DNA-dependent; apoptosis; multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; multicellular organismal homeostasis; embryonic camera-type eye development; post-embryonic development; cardiac muscle contraction; hair cycle |
| NCBI Summary: | IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8WUF5 |
| NCBI GenInfo Identifier: | 92090607 |
| NCBI Gene ID: | 10848 |
| NCBI Accession: | Q8WUF5.4 |
| UniProt Secondary Accession: | Q8WUF5,Q5I1X5, |
| UniProt Related Accession: | Q8WUF5 |
| Molecular Weight: | 828 |
| NCBI Full Name: | RelA-associated inhibitor |
| NCBI Synonym Full Names: | protein phosphatase 1, regulatory subunit 13 like |
| NCBI Official Symbol: | PPP1R13L |
| NCBI Official Synonym Symbols: | RAI; RAI4; IASPP; NKIP1 |
| NCBI Protein Information: | relA-associated inhibitor; protein iASPP; PPP1R13B-like protein; retinoic acid induced 4; inhibitor of ASPP protein; NFkB interacting protein 1; NFkB-interacting protein 1; inhibitor of apoptosis stimulating protein of p53; protein phosphatase 1, regulato |
| UniProt Protein Name: | RelA-associated inhibitor |
| UniProt Synonym Protein Names: | Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein |
| UniProt Gene Name: | PPP1R13L |
| UniProt Entry Name: | IASPP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPP1R13L antibody (CAB10462) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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