Anti-PPM1K Antibody (CAB16602)
- SKU:
- CAB16602
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PPM1K Antibody |
| Antibody SKU: | CAB16602 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 183-372 of human PPM1K (NP_689755.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, Mouse heart, Mouse brain, Rat heart, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 183-372 of human PPM1K (NP_689755.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLTS GTTA TVAL LRDG IELV VASV GDSR AILC RKGK PMKL TIDH TPER KDEK ERIK KCGG FVAW NSLG QPHV NGRL AMTR SIGD LDLK TSGV IAEP ETKR IKLH HADD SFLV LTTD GINF MVNS QEIC DFVN QCHD PNEA AHAV TEQA IQYG TEDN STAV VVPF GAWG KYKN SEIN FSFS RSFA SSGR WA |
| Gene ID: | 152926 |
| Uniprot: | Q8N3J5 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 16kDa/25kDa/40kDa |
| Observed MW: | 41kDa |
| Synonyms: | PPM1K, BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07 |
| Background: | This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. |
| UniProt Protein Function: | PPM1K: Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. Belongs to the PP2C family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q22.1 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:metal ion binding; protein binding; protein serine/threonine phosphatase activity Biological Process: branched chain family amino acid catabolic process; protein amino acid dephosphorylation Disease: Maple Syrup Urine Disease, Mild Variant |
| NCBI Summary: | This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012] |
| UniProt Code: | Q8N3J5 |
| NCBI GenInfo Identifier: | 74750962 |
| NCBI Gene ID: | 152926 |
| NCBI Accession: | Q8N3J5.1 |
| UniProt Secondary Accession: | Q8N3J5,Q05CT5, Q49AB5, Q4W5E6, Q56AN8, Q8IUZ7, Q8IXG7 Q8ND70, Q96NT4, B2RAZ1, |
| UniProt Related Accession: | Q8N3J5 |
| Molecular Weight: | 16,759 Da |
| NCBI Full Name: | Protein phosphatase 1K, mitochondrial |
| NCBI Synonym Full Names: | protein phosphatase, Mg2+/Mn2+ dependent 1K |
| NCBI Official Symbol: | PPM1K |
| NCBI Official Synonym Symbols: | BDP; PTMP; PP2Cm; MSUDMV; PP2Ckappa; UG0882E07 |
| NCBI Protein Information: | protein phosphatase 1K, mitochondrial |
| UniProt Protein Name: | Protein phosphatase 1K, mitochondrial |
| UniProt Synonym Protein Names: | PP2C domain-containing protein phosphatase 1K; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C isoform kappa; PP2C-kappa |
| Protein Family: | Protein phosphatase |
| UniProt Gene Name: | PPM1K |
| UniProt Entry Name: | PPM1K_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPM1K antibody (CAB16602) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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