| Background: | This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| UniProt Protein Function: | PPIL1: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. |
| UniProt Protein Details: | Protein type:Isomerase; Spliceosome; EC 5.2.1.8; Cyclophilin Chromosomal Location of Human Ortholog: 6p21.1 Molecular Function:peptidyl-prolyl cis-trans isomerase activity; protein binding Biological Process: nuclear mRNA splicing, via spliceosome |
| NCBI Summary: | This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3C6 |
| NCBI GenInfo Identifier: | 20177874 |
| NCBI Gene ID: | 51645 |
| NCBI Accession: | Q9Y3C6.1 |
| UniProt Secondary Accession: | Q9Y3C6,O15001, Q5TDC9, |
| UniProt Related Accession: | Q9Y3C6 |
| Molecular Weight: | 18,237 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase-like 1 |
| NCBI Synonym Full Names: | peptidylprolyl isomerase like 1 |
| NCBI Official Symbol: | PPIL1 |
| NCBI Official Synonym Symbols: | CYPL1; hCyPX; PPIase; CGI-124 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase-like 1 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase-like 1 |
| UniProt Synonym Protein Names: | Rotamase PPIL1 |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPIL1 |
| UniProt Entry Name: | PPIL1_HUMAN |
