Anti-PPID Antibody (CAB6949)
- SKU:
- CAB6949
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-PPID Antibody |
| Antibody SKU: | CAB6949 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 161-370 of human PPID (NP_005029.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, NIH/3T3, MCF7, U-87MG, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 161-370 of human PPID (NP_005029.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ILEN VEVK GEKP AKLC VIAE CGEL KEGD DGGI FPKD GSGD SHPD FPED ADID LKDV DKIL LITE DLKN IGNT FFKS QNWE MAIK KYAE VLRY VDSS KAVI ETAD RAKL QPIA LSCV LNIG ACKL KMSN WQGA IDSC LEAL ELDP SNTK ALYR RAQG WQGL KEYD QALA DLKK AQGI APED KAIQ AELL KVKQ KIKA QKDK EKAV YAKM FA |
| Gene ID: | 5481 |
| Uniprot: | Q08752 |
| Cellular Location: | Cytoplasm, Nucleus, nucleolus, nucleoplasm |
| Calculated MW: | 40kDa |
| Observed MW: | 41kDa |
| Synonyms: | PPID, CYP-40, CYPD |
| Background: | The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. |
| UniProt Protein Function: | PPID: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIase D subfamily. |
| UniProt Protein Details: | Protein type:Nucleolus; Isomerase; EC 5.2.1.8 Chromosomal Location of Human Ortholog: 4q31.3 Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function:cyclosporin A binding; estrogen receptor binding; heat shock protein binding; Hsp70 protein binding; Hsp90 protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; transcription factor binding Biological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of protein secretion; positive regulation of viral genome replication; protein complex assembly; protein folding; release of virus from host |
| NCBI Summary: | The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q08752 |
| NCBI GenInfo Identifier: | 729274 |
| NCBI Gene ID: | 5481 |
| NCBI Accession: | Q08752.3 |
| UniProt Secondary Accession: | Q08752,B2R9V2, |
| UniProt Related Accession: | Q08752 |
| Molecular Weight: | 40,764 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase D |
| NCBI Synonym Full Names: | peptidylprolyl isomerase D |
| NCBI Official Symbol: | PPID |
| NCBI Official Synonym Symbols: | CYPD; CYP-40 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase D |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase D |
| UniProt Synonym Protein Names: | 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Cyclophilin-related protein; Rotamase D |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPID |
| UniProt Entry Name: | PPID_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPID antibody (CAB6949) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded rat brain using PPID Antibody (CAB6949) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human kidney using PPID Antibody (CAB6949) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using PPID Antibody (CAB6949) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A-549 cells using PPID antibody (CAB6949). Blue: DAPI for nuclear staining. |
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