| UniProt Protein Function: | liprin beta 1: a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Five alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 12p12.1 Cellular Component: focal adhesion; plasma membrane Biological Process: cell adhesion |
| NCBI Summary: | The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86W92 |
| NCBI GenInfo Identifier: | 90185247 |
| NCBI Gene ID: | 8496 |
| NCBI Accession: | Q86W92.2 |
| UniProt Secondary Accession: | Q86W92,O75336, Q86X70, Q9NY03, Q9ULJ0, |
| UniProt Related Accession: | Q86W92 |
| Molecular Weight: | 1011 |
| NCBI Full Name: | Liprin-beta-1 |
| NCBI Synonym Full Names: | PTPRF interacting protein, binding protein 1 (liprin beta 1) |
| NCBI Official Symbol: | PPFIBP1 |
| NCBI Official Synonym Symbols: | L2; SGT2; hSGT2; hSgt2p |
| NCBI Protein Information: | liprin-beta-1; liprin-beta 1; liprin related protein; PTPRF-interacting protein-binding protein 1; protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; protein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1 |
| UniProt Protein Name: | Liprin-beta-1 |
| UniProt Synonym Protein Names: | Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; PTPRF-interacting protein-binding protein 1; hSGT2 |
| Protein Family: | Liprin |
| UniProt Gene Name: | PPFIBP1 |
| UniProt Entry Name: | LIPB1_HUMAN |
