Anti-PPFIA1 Antibody (CAB10388)
- SKU:
- CAB10388
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PPFIA1 Antibody |
| Antibody SKU: | CAB10388 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 660-800 of human PPFIA1 (NP_003617.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, 293T, MCF7, DU145 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 660-800 of human PPFIA1 (NP_003617.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IESR VGSG SLDN LGRF RSMS SIPP YPAS SLAS SSPP GSGR STPR RIPH SPAR EVDR LGVM TLLP PSRE EVRD DKTT IKCE TSPP SSPR ALRL DRLH KGAL HTVS HEDI RDIR NSTG SQDG PVSN PSSS NSSQ DSLH KAPK K |
| Gene ID: | 8500 |
| Uniprot: | Q13136 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 133kDa/135kDa |
| Observed MW: | 136kDa |
| Synonyms: | PPFIA1, LIP.1, LIP1, LIPRIN |
| Background: | The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| UniProt Protein Function: | liprin alpha 1: a ubiqutous member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 11q13.3 Cellular Component: focal adhesion; cytoplasm; presynaptic active zone; cytosol Molecular Function:signal transducer activity; protein binding Biological Process: synaptic transmission; negative regulation of stress fiber formation; glutamate secretion; cell-matrix adhesion; neurotransmitter secretion; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13136 |
| NCBI GenInfo Identifier: | 42558969 |
| NCBI Gene ID: | 8500 |
| NCBI Accession: | Q13136.1 |
| UniProt Related Accession: | Q13136 |
| Molecular Weight: | |
| NCBI Full Name: | Liprin-alpha-1 |
| NCBI Synonym Full Names: | PTPRF interacting protein alpha 1 |
| NCBI Official Symbol: | PPFIA1 |
| NCBI Official Synonym Symbols: | LIP1; LIP.1; LIPRIN |
| NCBI Protein Information: | liprin-alpha-1 |
| UniProt Protein Name: | Liprin-alpha-1 |
| UniProt Synonym Protein Names: | LAR-interacting protein 1; LIP-1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; PTPRF-interacting protein alpha-1 |
| Protein Family: | Lipoyl synthase |
| UniProt Gene Name: | PPFIA1 |
| UniProt Entry Name: | LIPA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPFIA1 antibody (CAB10388) at 1:5000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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