Anti-POMP Antibody (CAB9067)
- SKU:
- CAB9067
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-POMP Antibody |
| Antibody SKU: | CAB9067 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human POMP (NP_057016.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, HepG2, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human POMP (NP_057016.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNAR GLGS ELKD SIPV TELS ASGP FESH DLLR KGFS CVKN ELLP SHPL ELSE KNFQ LNQD KMNF STLR NIQG LFAP LKLQ MEFK AVQQ VQRL PFLS SSNL SLDV LRGN DETI GFED ILND PSQS EVMG EPHL MVEY KLGL L |
| Gene ID: | 51371 |
| Uniprot: | Q9Y244 |
| Cellular Location: | Cytoplasm, Microsome membrane, Nucleus, cytosol |
| Calculated MW: | 15kDa |
| Observed MW: | 16kDa |
| Synonyms: | POMP, C13orf12, HSPC014, PNAS-110, UMP1 |
| Background: | The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder. |
| UniProt Protein Function: | POMP: Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum. Defects in POMP are the cause of keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK). KLICK is a keratinizing disorder characterized by ichthyosis, palmoplantar keratoderma with constricting bands around fingers, flexural deformities of fingers and keratotic papules in a linear distribution on the flexural side of large joints. Histological examination of the skin of affected individuals shows hypertrophy and hyperplasia of the spinous, granular and horny epidermal layer. Belongs to the POMP/UMP1 family. |
| UniProt Protein Details: | Protein type:Proteasome complex Chromosomal Location of Human Ortholog: 13q12.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: proteasome assembly Disease: Keratosis Linearis With Ichthyosis Congenita And Sclerosing Keratoderma |
| NCBI Summary: | The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.[provided by RefSeq, Aug 2010] |
| UniProt Code: | Q9Y244 |
| NCBI GenInfo Identifier: | 74753466 |
| NCBI Gene ID: | 51371 |
| NCBI Accession: | Q9Y244.1 |
| UniProt Secondary Accession: | Q9Y244,Q9HB69, A5HKJ2, D6MXU3, |
| UniProt Related Accession: | Q9Y244 |
| Molecular Weight: | 15,789 Da |
| NCBI Full Name: | Proteasome maturation protein |
| NCBI Synonym Full Names: | proteasome maturation protein |
| NCBI Official Symbol: | POMP |
| NCBI Official Synonym Symbols: | UMP1; HSPC014; C13orf12; PNAS-110 |
| NCBI Protein Information: | proteasome maturation protein |
| UniProt Protein Name: | Proteasome maturation protein |
| UniProt Synonym Protein Names: | Proteassemblin; Protein UMP1 homolog; hUMP1; Voltage-gated K channel beta subunit 4.1 |
| Protein Family: | Proteasome maturation protein |
| UniProt Gene Name: | POMP |
| UniProt Entry Name: | POMP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using POMP antibody (CAB9067) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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