Anti-PNPLA3 Antibody (CAB6694)
- SKU:
- CAB6694
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-PNPLA3 Antibody |
| Antibody SKU: | CAB6694 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 377-481 of human PNPLA3 (NP_079501.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, Mouse lung, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 377-481 of human PNPLA3 (NP_079501.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PDMP DDVL WLQW VTSQ VFTR VLMC LLPA SRSQ MPVS SQQA SPCT PEQD WPCW TPCS PKGC PAET KAEA TPRS ILRS SLNF FLGN KVPA GAEG LSTF PSFS LEKS L |
| Gene ID: | 80339 |
| Uniprot: | Q9NST1 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 52kDa |
| Observed MW: | 53kDa |
| Synonyms: | PNPLA3, ADPN, C22orf20 |
| Background: | The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. |
| UniProt Protein Function: | PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Phospholipase; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 3.1.1.3; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - phenylalanine; Transferase; Amino Acid Metabolism - tyrosine; Membrane protein, integral Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane Molecular Function:acylglycerol O-acyltransferase activity; diolein transacylation activity; lipoprotein lipase activity; mono-olein transacylation activity; phospholipase A2 activity; triacylglycerol lipase activity Biological Process: triacylglycerol biosynthetic process; triacylglycerol catabolic process |
| NCBI Summary: | The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NST1 |
| NCBI GenInfo Identifier: | 32469599 |
| NCBI Gene ID: | 80339 |
| NCBI Accession: | Q9NST1.2 |
| UniProt Secondary Accession: | Q9NST1,Q6P1A1, Q96CB4, B0QYI0, B2RCL3, B3KW00, |
| UniProt Related Accession: | Q9NST1 |
| Molecular Weight: | |
| NCBI Full Name: | Patatin-like phospholipase domain-containing protein 3 |
| NCBI Synonym Full Names: | patatin like phospholipase domain containing 3 |
| NCBI Official Symbol: | PNPLA3 |
| NCBI Official Synonym Symbols: | ADPN; C22orf20; iPLA(2)epsilon |
| NCBI Protein Information: | patatin-like phospholipase domain-containing protein 3 |
| UniProt Protein Name: | Patatin-like phospholipase domain-containing protein 3 |
| UniProt Synonym Protein Names: | Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon |
| Protein Family: | Patatin-like phospholipase domain-containing protein |
| UniProt Gene Name: | PNPLA3 |
| UniProt Entry Name: | PLPL3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PNPLA3 Antibody (CAB6694) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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