Anti-PMPCB Antibody (CAB4312)
- SKU:
- CAB4312
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PMPCB Antibody |
| Antibody SKU: | CAB4312 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-380 of human PMPCB (NP_004270.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, MCF7, HT-1080, Mouse liver, Mouse kidney, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-380 of human PMPCB (NP_004270.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GTKK RSQL DLEL EIEN MGAH LNAY TSRE QTVY YAKA FSKD LPRA VEIL ADII QNST LGEA EIER ERGV ILRE MQEV ETNL QEVV FDYL HATA YQNT ALGR TILG PTEN IKSI SRKD LVDY ITTH YKGP RIVL AAAG GVSH DELL DLAK FHFG DSLC THKG EIPA LPPC KFTG SEIR VRDD KMPL AHLA IAVE AVGW AHPD TICL MVAN TLIG NWDR SFGG GMNL SSKL AQLT CHGN LCHS FQSF NTSY TDTG LWGL YMVC ESST VADM LHV |
| Gene ID: | 9512 |
| Uniprot: | O75439 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 54kDa |
| Observed MW: | 50kDa |
| Synonyms: | PMPCB, Beta-MPP, MPP11, MPPB, MPPP52, P-52 |
| Background: | This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. |
| UniProt Protein Function: | PMPCB: Cleaves presequences (transit peptides) from mitochondrial protein precursors. Belongs to the peptidase M16 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Protease; EC 3.4.24.64 Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: mitochondrial matrix; mitochondrial inner membrane Molecular Function:metal ion binding; metalloendopeptidase activity Biological Process: cellular protein metabolic process; proteolysis; protein targeting to mitochondrion |
| NCBI Summary: | This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75439 |
| NCBI GenInfo Identifier: | 29840827 |
| NCBI Gene ID: | 9512 |
| NCBI Accession: | O75439.2 |
| UniProt Secondary Accession: | O75439,O60416, Q96FV4, |
| UniProt Related Accession: | O75439 |
| Molecular Weight: | 489 |
| NCBI Full Name: | Mitochondrial-processing peptidase subunit beta |
| NCBI Synonym Full Names: | peptidase (mitochondrial processing) beta |
| NCBI Official Symbol: | PMPCB |
| NCBI Official Synonym Symbols: | MPPB; P-52; MPP11; MPPP52; Beta-MPP |
| NCBI Protein Information: | mitochondrial-processing peptidase subunit beta; mitochondrial processing peptidase beta subunit |
| UniProt Protein Name: | Mitochondrial-processing peptidase subunit beta |
| UniProt Synonym Protein Names: | Beta-MPP; P-52 |
| UniProt Gene Name: | PMPCB |
| UniProt Entry Name: | MPPB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PMPCB antibody (CAB4312) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human stomach using PMPCB antibody (CAB4312) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat kidney using PMPCB antibody (CAB4312) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using PMPCB antibody (CAB4312) at dilution of 1:100 (40x lens). |
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