Anti-PMPCA Antibody (CAB9965)
- SKU:
- CAB9965
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PMPCA Antibody |
| Antibody SKU: | CAB9965 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 456-525 of human PMPCA (NP_055975.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, MCF7, Raji, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 456-525 of human PMPCA (NP_055975.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TRSR KLPH ELCT LIRN VKPE DVKR VASK MLRG KPAV AALG DLTD LPTY EHIQ TALS SKDG RLPR TYRL FR |
| Gene ID: | 23203 |
| Uniprot: | Q10713 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 44kDa/58kDa |
| Observed MW: | 110kDa |
| Synonyms: | PMPCA, Alpha-MPP, INPP5E, P-55, SCAR2 |
| Background: | The protein encoded by this gene is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins. Defects in this gene are a cause of spinocerebellar ataxia, autosomal recessive 2. |
| UniProt Protein Function: | PMPCA: Cleaves presequences (transit peptides) from mitochondrial protein precursors. Belongs to the peptidase M16 family. |
| UniProt Protein Details: | Protein type:EC 3.4.24.64; Protease; Mitochondrial Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: extracellular space; mitochondrion; mitochondrial matrix; mitochondrial inner membrane Molecular Function:metal ion binding; metalloendopeptidase activity Biological Process: cellular protein metabolic process; proteolysis; protein targeting to mitochondrion |
| UniProt Code: | Q10713 |
| NCBI GenInfo Identifier: | 24308013 |
| NCBI Gene ID: | 23203 |
| NCBI Accession: | NP_055975.1 |
| UniProt Secondary Accession: | Q10713,Q16639, Q5SXM9, Q8N513, B4DKL3, E7ET61, |
| UniProt Related Accession: | Q10713 |
| Molecular Weight: | 58253 |
| NCBI Full Name: | mitochondrial-processing peptidase subunit alpha isoform 1 |
| NCBI Synonym Full Names: | peptidase (mitochondrial processing) alpha |
| NCBI Official Symbol: | PMPCA |
| NCBI Official Synonym Symbols: | P-55; INPP5E; Alpha-MPP |
| NCBI Protein Information: | mitochondrial-processing peptidase subunit alpha |
| UniProt Protein Name: | Mitochondrial-processing peptidase subunit alpha |
| UniProt Synonym Protein Names: | Alpha-MPP; P-55 |
| Protein Family: | Mitochondrial-processing peptidase |
| UniProt Gene Name: | PMPCA |
| UniProt Entry Name: | MPPA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PMPCA antibody (CAB9965) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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