Anti-PLXNB1 Antibody (CAB10010)
- SKU:
- CAB10010
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PLXNB1 Antibody |
| Antibody SKU: | CAB10010 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-470 of human PLXNB1 (NP_002664.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-470 of human PLXNB1 (NP_002664.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RVCL RDQH YYSY VELP LACE GGRY GLIQ AAAV ATSR EVAH GEVL FAAF SSAA PPTV GRPP SAAA GASG ASAL CAFP LDEV DRLA NRTR DACY TREG RAED GTEV AYIE YDVN SDCA QLPV DTLD AYPC GSDH TPSP MASR VPLE ATPI LEWP GIQL TAVA VTME DGHT IAFL GDSQ GQLH RVYL GPGS DGHP YSTQ SIQQ GSAV SRDL TFDG TFEH LYVM T |
| Gene ID: | 5364 |
| Uniprot: | O43157 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 78kDa/214kDa/232kDa |
| Observed MW: | 232kDa |
| Synonyms: | PLXNB1, PLEXIN-B1, PLXN5, SEP, plexin-B1 |
| Background: |
| UniProt Protein Function: | PLXNB1: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the plexin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; intracellular Molecular Function:protein binding; transmembrane receptor activity; semaphorin receptor activity; GTPase activating protein binding; receptor activity; semaphorin receptor binding Biological Process: positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; axon guidance; cell migration; positive regulation of axonogenesis; negative regulation of osteoblast proliferation; negative regulation of cell adhesion; signal transduction; neurite morphogenesis; regulation of cytoskeleton organization and biogenesis |
| UniProt Code: | O43157 |
| NCBI GenInfo Identifier: | 194272180 |
| NCBI Gene ID: | 5364 |
| NCBI Accession: | NP_001123554.1 |
| UniProt Secondary Accession: | O43157,Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93, A6H8Y2, |
| UniProt Related Accession: | O43157 |
| Molecular Weight: | 232,298 Da |
| NCBI Full Name: | plexin-B1 |
| NCBI Synonym Full Names: | plexin B1 |
| NCBI Official Symbol: | PLXNB1 |
| NCBI Official Synonym Symbols: | SEP; PLXN5; KIAA0407; MGC149167; PLEXIN-B1 |
| NCBI Protein Information: | plexin-B1; plexin 5; OTTHUMP00000164806; OTTHUMP00000210032; OTTHUMP00000210033; semaphorin receptor SEP |
| UniProt Protein Name: | Plexin-B1 |
| UniProt Synonym Protein Names: | Semaphorin receptor SEP |
| Protein Family: | Plexin |
| UniProt Gene Name: | PLXNB1 |
| UniProt Entry Name: | PLXB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLXNB1 antibody (CAB10010) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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