Anti-PLGF Antibody (CAB1727)

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SKU:
CAB1727
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
Frequently bought together:

Description

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Antibody Name:Anti-PLGF Antibody
Antibody SKU:CAB1727
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-170 of human PLGF (NP_002623.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Mouse liver, HT-29, MCF7, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-170 of human PLGF (NP_002623.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPAV PPQQ WALS AGNG SSEV EVVP FQEV WGRS YCRA LERL VDVV SEYP SEVE HMFS PSCV SLLR CTGC CGDE NLHC VPVE TANV TMQL LKIR SGDR PSYV ELTF SQHV RCEC RPLR EKMK PERR RPKG RGKR RREK QRPT DCHL CGDA VPRR
Gene ID:5228
Uniprot:P49763
Cellular Location:Secreted
Calculated MW:16kDa/19kDa/24kDa/27kDa
Observed MW:25kDa/50kDa
Synonyms:PGF, D12S1900, PGFL, PIGF, PLGF, PlGF-2, SHGC-10760
Background:This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.
UniProt Protein Function:PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function:heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity

Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation

NCBI Summary:This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
UniProt Code:P49763
NCBI GenInfo Identifier:17380553
NCBI Gene ID:5228
NCBI Accession:P49763.2
UniProt Secondary Accession:P49763,Q07101, Q9BV78, Q9Y6S8,
UniProt Related Accession:P49763
Molecular Weight:19,338 Da
NCBI Full Name:Placenta growth factor
NCBI Synonym Full Names:placental growth factor
NCBI Official Symbol:PGF  
NCBI Official Synonym Symbols:PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760  
NCBI Protein Information:placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein
UniProt Protein Name:Placenta growth factor
Protein Family:Placenta growth factor
UniProt Gene Name:PGF  
UniProt Entry Name:PLGF_HUMAN
Anti-PLGF Antibody (CAB1727)Western blot analysis of extracts of various cell lines, using PLGF antibody (CAB1727) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).
Anti-PLGF Antibody (CAB1727)Western blot analysis of extracts of various cell lines, using PLGF antibody (CAB1727) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s.
Anti-PLGF Antibody (CAB1727)Immunohistochemistry of paraffin-embedded human colon using PLGF Antibody (CAB1727) at dilution of 1:100 (40x lens).

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