Anti-PLG Antibody (CAB3320)
- SKU:
- CAB3320
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| Antibody Name: | Anti-PLG Antibody |
| Antibody SKU: | CAB3320 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human PLG (NP_000292.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Human plasma, Mouse serum, Rat serum |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human PLG (NP_000292.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EPLD DYVN TQGA SLFS VTKK QLGA GSIE ECAA KCEE DEEF TCRA FQYH SKEQ QCVI MAEN RKSS IIIR MRDV VLFE KKVY LSEC KTGN GKNY RGTM SKTK NGIT CQKW SSTS PHRP RFSP ATHP SEGL EENY CRNP DNDP QGPW CYTT DPEK RYDY CDIL ECEE ECMH CSGE NYDG KISK TMSG LECQ AWDS QSPH AHGY IPSK FPNK NLKK NYCR NPDR ELRP WCFT TDPN KRWE LCDI PRCT TPPP SSGP TYQC LKGT GENY RGNV AVTV SGHT CQHW S |
| Gene ID: | 5340 |
| Uniprot: | P00747 |
| Cellular Location: | Secreted |
| Calculated MW: | 90kDa |
| Observed MW: | 125kDa |
| Synonyms: | PLG |
| Background: | The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. |
| NCBI Summary: | The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] |
| UniProt Code: | P00747 |
| NCBI GenInfo Identifier: | 130316 |
| NCBI Gene ID: | 5340 |
| NCBI Accession: | P00747.2 |
| UniProt Secondary Accession: | P00747,Q15146, Q5TEH4, Q6PA00, |
| UniProt Related Accession: | P00747 |
| Molecular Weight: | 90,569 Da |
| NCBI Full Name: | Plasminogen |
| NCBI Synonym Full Names: | plasminogen |
| NCBI Official Symbol: | PLG |
| NCBI Protein Information: | plasminogen |
| UniProt Protein Name: | Plasminogen |
| Protein Family: | Plasminogen |
| UniProt Gene Name: | PLG |
| UniProt Entry Name: | PLMN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLG antibody (CAB3320) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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