Anti-PLA2G7 Antibody (CAB9796)

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SKU:
CAB9796
Product type:
Antibody
Application:
WB
Application:
IHC
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-PLA2G7 Antibody
Antibody SKU:CAB9796
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 172-441 of human PLA2G7 (NP_005075.3).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Rat serum
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 172-441 of human PLA2G7 (NP_005075.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FIVA AVEH RDRS ASAT YYFK DQSA AEIG DKSW LYLR TLKQ EEET HIRN EQVR QRAK ECSQ ALSL ILDI DHGK PVKN ALDL KFDM EQLK DSID REKI AVIG HSFG GATV IQTL SEDQ RFRC GIAL DAWM FPLG DEVY SRIP QPLF FINS EYFQ YPAN IIKM KKCY SPDK ERKM ITIR GSVH QNFA DFTF ATGK IIGH MLKL KGDI DSNV AIDL SNKA SLAF LQKH LGLH KDFD QWDC LIEG DDEN LIPG TNIN TTNQ HIML QNSS GIEK YN
Gene ID:7941
Uniprot:Q13093
Cellular Location:Secreted, extracellular space
Calculated MW:50kDa
Observed MW:60kDa
Synonyms:PLA2G7, LDL-PLA2, LP-PLA2, PAFAD, PAFAH
Background:The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.
UniProt Protein Function:PLA2G7: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids. Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency (PAFAD). An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. Asthmatic individuals affected by this condition may manifest severe respiratory symptoms. Defects in PLA2G7 are a cause of susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. PLA2G7 variants can be a risk factor for the development of asthma and PLA2G7 may act as a modifier gene that modulates the severity of this disease. Defects in PLA2G7 are a cause of susceptibility to atopic hypersensitivity (ATOPY). A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma. Belongs to the AB hydrolase superfamily. Lipase family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; EC 3.1.1.47; Secreted; Hydrolase; Lipid Metabolism - ether lipid

Chromosomal Location of Human Ortholog: 6p21.2-p12

Cellular Component: cytoplasm; extracellular region

Molecular Function:calcium-independent phospholipase A2 activity; phospholipid binding; 1-alkyl-2-acetylglycerophosphocholine esterase activity

Biological Process: cellular protein metabolic process; lipid catabolic process; positive regulation of inflammatory response

Disease: Asthma, Susceptibility To; Ige Responsiveness, Atopic; Platelet-activating Factor Acetylhydrolase Deficiency

NCBI Summary:The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
UniProt Code:Q13093
NCBI GenInfo Identifier:2497687
NCBI Gene ID:7941
NCBI Accession:Q13093.1
UniProt Secondary Accession:Q13093,Q15692, Q5VTT1, Q8IVA2, A5HTT5,
UniProt Related Accession:Q13093
Molecular Weight:
NCBI Full Name:Platelet-activating factor acetylhydrolase
NCBI Synonym Full Names:phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
NCBI Official Symbol:PLA2G7  
NCBI Official Synonym Symbols:PAFAD; PAFAH; LP-PLA2; LDL-PLA2  
NCBI Protein Information:platelet-activating factor acetylhydrolase; LDL-PLA(2); gVIIA-PLA2; PAF 2-acylhydrolase; PAF acetylhydrolase; group-VIIA phospholipase A2; LDL-associated phospholipase A2; lipoprotein-associated phospholipase A2; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase
UniProt Protein Name:Platelet-activating factor acetylhydrolase
UniProt Synonym Protein Names:1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA(2); PAF 2-acylhydrolase
UniProt Gene Name:PLA2G7  
UniProt Entry Name:PAFA_HUMAN
Anti-PLA2G7 Polyclonal Antibody (CAB9796)Western blot analysis of extracts of Rat serum, using PLA2G7 Rabbit pAb (CAB9796) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-PLA2G7 Polyclonal Antibody (CAB9796)Immunohistochemistry of paraffin-embedded human prostate using PLA2G7 antibody (CAB9796) at dilution of 1:100 (40x lens).

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