Anti-PLA2G1B Antibody (CAB5478)

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SKU:
CAB5478
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-PLA2G1B Antibody
Antibody SKU:CAB5478
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-148 of human PLA2G1B (NP_000919.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse
Positive Samples:A-549, Mouse pancreas, Mouse small intestine
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-148 of human PLA2G1B (NP_000919.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AVWQ FRKM IKCV IPGS DPFL EYNN YGCY CGLG GSGT PVDE LDKC CQTH DNCY DQAK KLDS CKFL LDNP YTHT YSYS CSGS AITC SSKN KECE AFIC NCDR NAAI CFSK APYN KAHK NLDT KKYC QS
Gene ID:5319
Uniprot:P04054
Cellular Location:Secreted
Calculated MW:16kDa
Observed MW:16kDa
Synonyms:PLA2G1B, PLA2, PLA2A, PPLA2
Background:This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response.
UniProt Protein Function:PLA2G1B: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family.
UniProt Protein Details:

Protein type:Lipid Metabolism - arachidonic acid; Secreted, signal peptide; Secreted; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Phospholipase; Lipid Metabolism - alpha-linolenic acid; EC 3.1.1.4; DNA replication; Lipid Metabolism - linoleic acid

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: extracellular space; cell surface; extracellular region; secretory granule

Molecular Function:phospholipase A2 activity; calcium-dependent phospholipase A2 activity; bile acid binding; calcium ion binding; receptor binding

Biological Process: positive regulation of immune response; activation of MAPK activity; neutrophil mediated immunity; activation of phospholipase A2; glucose transport; signal transduction; activation of NF-kappaB transcription factor; phosphatidylcholine metabolic process; positive regulation of fibroblast proliferation; phospholipid metabolic process; fatty acid biosynthetic process; neutrophil chemotaxis; multicellular organismal lipid catabolic process; glycerophospholipid biosynthetic process; actin filament organization; arachidonic acid secretion; leukotriene biosynthetic process; defense response to Gram-positive bacterium; cellular response to insulin stimulus; innate immune response in mucosa; positive regulation of protein secretion; antibacterial humoral response; phosphatidic acid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; interleukin-8 production; positive regulation of DNA replication

NCBI Summary:This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
UniProt Code:P04054
NCBI GenInfo Identifier:4505847
NCBI Gene ID:5319
NCBI Accession:NP_000919.1
UniProt Secondary Accession:P04054,Q3KPI1, B2R4H5,
UniProt Related Accession:P04054
Molecular Weight:16,360 Da
NCBI Full Name:phospholipase A2
NCBI Synonym Full Names:phospholipase A2, group IB (pancreas)
NCBI Official Symbol:PLA2G1B  
NCBI Official Synonym Symbols:PLA2; PLA2A; PPLA2  
NCBI Protein Information:phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B
UniProt Protein Name:Phospholipase A2
UniProt Synonym Protein Names:Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B
Protein Family:Phospholipase
UniProt Gene Name:PLA2G1B  
UniProt Entry Name:PA21B_HUMAN
Anti-PLA2G1B Antibody (CAB5478)Western blot analysis of extracts of various cell lines, using PLA2G1B antibody (CAB5478) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-PLA2G1B Antibody (CAB5478)Immunohistochemistry of paraffin-embedded mouse pancreas using PLA2G1B antibody (CAB5478) at dilution of 1:100 (40x lens).

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