Anti-PLA2G12A Antibody (CAB15902)

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SKU:
CAB15902
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-PLA2G12A Antibody
Antibody SKU:CAB15902
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PLA2G12A (NP_110448.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HepG2, HeLa, Mouse pancreas
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PLA2G12A (NP_110448.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MALL SRPA LTLL LLLM AAVV RCQE QAQT TDWR ATLK TIRN GVHK IDTY LNAA LDLL GGED GLCQ YKCS DGSK PFPR YGYK PSPP NGCG SPLF GVHL NIGI
Gene ID:81579
Uniprot:Q9BZM1
Cellular Location:Cytoplasm, Secreted
Calculated MW:21kDa
Observed MW:17kDa
Synonyms:PLA2G12A, GXII, PLA2G12, ROSSY
Background:Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).
UniProt Protein Function:PLA2G12A: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. Belongs to the phospholipase A2 family.
UniProt Protein Details:

Protein type:Lipid Metabolism - glycerophospholipid; Secreted; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - linoleic acid; Secreted, signal peptide; EC 3.1.1.4; Lipid Metabolism - ether lipid; Lipid Metabolism - arachidonic acid; Endoplasmic reticulum; Phospholipase

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: extracellular region

Molecular Function:phospholipase A2 activity

Biological Process: phosphatidic acid biosynthetic process

NCBI Summary:Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9BZM1
NCBI GenInfo Identifier:20143881
NCBI Gene ID:81579
NCBI Accession:Q9BZM1.1
UniProt Secondary Accession:Q9BZM1,Q9BZ89,
UniProt Related Accession:Q9BZM1
Molecular Weight:21,067 Da
NCBI Full Name:Group XIIA secretory phospholipase A2
NCBI Synonym Full Names:phospholipase A2 group XIIA
NCBI Official Symbol:PLA2G12A  
NCBI Official Synonym Symbols:GXII; ROSSY; PLA2G12  
NCBI Protein Information:group XIIA secretory phospholipase A2
UniProt Protein Name:Group XIIA secretory phospholipase A2
UniProt Synonym Protein Names:Phosphatidylcholine 2-acylhydrolase 12A
Protein Family:Group XIIA secretory phospholipase
UniProt Gene Name:PLA2G12A  
UniProt Entry Name:PG12A_HUMAN
Anti-PLA2G12A Antibody (CAB15902)Western blot analysis of extracts of various cell lines, using PLA2G12A antibody (CAB15902) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 150s.

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