Anti-PKC epsilon Antibody (CAB4998)

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SKU:
CAB4998
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PKCE
nPKC-epsilon
Frequently bought together:

Description

Product Name:PKC epsilon Rabbit mAb
Product Code:CAB4998
Size:20uL, 50uL, 100uL
Synonyms:PKCE, nPKC-epsilon
Applications:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PKC epsilon
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse lung
Immunogen:A synthesized peptide derived from human PKC epsilon
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5581
Uniprot:Q02156
Cellular Location:Cell membrane, Cytoplasm, Nucleus, cytoskeleton, perinuclear region
Calculated MW:84kDa
Observed MW:82KDa
UniProt Protein Function:PKCE: an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction.
UniProt Protein Details:

Protein type:Kinase, protein; Protein kinase, AGC; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Eta subfamily

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; perinuclear region of cytoplasm; plasma membrane

Molecular Function:actin monomer binding; enzyme activator activity; enzyme binding; protein binding; protein kinase C activity; protein serine/threonine kinase activity; signal transducer activity

Biological Process: apoptosis; lipopolysaccharide-mediated signaling pathway; peptidyl-serine phosphorylation; phospholipase C activation; platelet activation; positive regulation of actin filament polymerization; positive regulation of cytokinesis; protein amino acid phosphorylation; signal transduction

NCBI Summary:Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
UniProt Code:Q02156
NCBI GenInfo Identifier:400135
NCBI Gene ID:5581
NCBI Accession:Q02156.1
UniProt Secondary Accession:Q02156,Q32MQ3, Q53SL4, Q53SM5, Q9UE81, B0LPH7,
UniProt Related Accession:Q02156
Molecular Weight:83,674 Da
NCBI Full Name:Protein kinase C epsilon type
NCBI Synonym Full Names:protein kinase C epsilon
NCBI Official Symbol:PRKCE  
NCBI Official Synonym Symbols:PKCE; nPKC-epsilon  
NCBI Protein Information:protein kinase C epsilon type
UniProt Protein Name:Protein kinase C epsilon type
UniProt Synonym Protein Names:nPKC-epsilon
Protein Family:Protein kinase
UniProt Gene Name:PRKCE  
UniProt Entry Name:KPCE_HUMAN

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