| UniProt Protein Function: | PIWIL2: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors. Interacts with DDX4, MAEL, EIF3A, EIF4E, EIF4G, PRMT5 and WDR77. Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes. Interacts (when methylated on arginine residues) with TDRD1. Expressed in adult testis and in most tumors. Belongs to the argonaute family. Piwi subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis; Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: cytoplasm Biological Process: DNA methylation during gametogenesis; germ-line stem cell maintenance; oogenesis; positive regulation of translation; RNA-mediated gene silencing |
| NCBI Summary: | PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8TC59 |
| NCBI GenInfo Identifier: | 74730558 |
| NCBI Gene ID: | 55124 |
| NCBI Accession: | Q8TC59.1 |
| UniProt Secondary Accession: | Q8TC59,Q96SW6, Q9NW28, A8K4S3, A8K8S5, B0AZN9, B0AZP2 B4DR22, E7ECA4, |
| UniProt Related Accession: | Q8TC59 |
| Molecular Weight: | 105,760 Da |
| NCBI Full Name: | Piwi-like protein 2 |
| NCBI Synonym Full Names: | piwi like RNA-mediated gene silencing 2 |
| NCBI Official Symbol: | PIWIL2 |
| NCBI Official Synonym Symbols: | CT80; HILI; mili; PIWIL1L |
| NCBI Protein Information: | piwi-like protein 2 |
| UniProt Protein Name: | Piwi-like protein 2 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 80; CT80 |
| Protein Family: | Piwi-like protein |
| UniProt Gene Name: | PIWIL2 |
| UniProt Entry Name: | PIWL2_HUMAN |
